Premenopausal hysterectomy is associated with increased brain ferritin iron.
Premenopausal hysterectomy is associated with increased brain ferritin iron.
复制标题
绝经前子宫切除术与脑铁蛋白铁含量增加有关。
DOI：
10.1016/j.neurobiolaging.2011.08.002
复制
发表时间：
2011
影响因子：
4.2
通讯作者：
Bartzokis,George
中科院分区：
文献类型：
--
作者：
Tishler,ToddA;Raven,ErikaP;Lu,PoH;Altshuler,LoriL;Bartzokis,George
铁是触发少突胶质细胞髓鞘形成所必需的，然而，在灰质（GM）中，铁随着年龄的增长而增加，并与年龄相关的退行性脑疾病有关。女性的铁含量低于男性，无论是在外周还是在大脑中，特别是在白色物质（WM）中，可能是由于月经期间的铁损失。我们检验了子宫切除术可以增加WM铁水平的假设。我们评估了39名绝经后妇女，其中15名绝经前子宫切除术，3 WM和5灰质区域，利用一种有效的磁共振成像技术，称为场依赖性R2增加（FDRI），量化铁蛋白铁。纳入一组54例匹配的男性受试者进行比较。在女性中，子宫切除术与额叶WM铁显着较高。男性在3个脑区的铁水平高于未行子宫切除术的女性，但在任何区域与行子宫切除术的女性无差异。结果表明，与脑铁相关的失血是脑铁性别差异的一个来源。脑铁可能受到外周铁水平的影响，因此可能是与年龄相关的退行性疾病的一个可改变的风险因素。
Iron is essential for triggering oligodendrocytes to myelinate, however, in gray matter (GM) iron increases with age and is associated with age-related degenerative brain diseases. Women have lower iron levels than men, both in the periphery and in the brain, particularly in white matter (WM), possibly due to iron loss through menstruation. We tested the hypothesis that hysterectomy could increase WM iron levels. We assessed 3 WM and 5 gray matter regions in 39 postmenopausal women, of whom 15 had premenopausal hysterectomy, utilizing a validated magnetic resonance imaging technique called field-dependent R2 increase (FDRI) that quantifies ferritin iron. A group of 54 matched male subjects was included for comparison. Amongst women, hysterectomy was associated with significantly higher frontal lobe WM iron. Men had higher iron levels than women without hysterectomy in 3 brain regions but did not differ from women with hysterectomy in any region. The results suggest that menstruation-associated blood loss is a source of gender differences in brain iron. It is possible that brain iron can be influenced by peripheral iron levels and may thus be a modifiable risk factor for age-related degenerative diseases.