Reproductive and metabolic features during puberty in sons of women with polycystic ovary syndrome
Reproductive and metabolic features during puberty in sons of women with polycystic ovary syndrome
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DOI：
10.1530/ec-17-0218
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发表时间：
2017-11-01
影响因子：
2.9
通讯作者：
Sir-Petermann, Teresa
中科院分区：
文献类型：
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作者：
Crisosto, Nicolas;Echiburu, Barbara;Sir-Petermann, Teresa
背景：宫内生活可能与多囊卵巢综合征（PCOS）的起源有关，多囊卵巢综合征母亲所生儿童的内分泌和代谢功能与遗传和性别无关。本研究的目的是评估多囊卵巢综合征女性的儿子在青春期的生殖和代谢功能。方法：对69例7 ~ 18岁PCOS儿子（PCOS）和84例对照进行Tanner分期评分匹配。进行了完整的体格检查，包括人体测量（体重、身高、腰围、臀部和身体质量指数）。进行口服葡萄糖耐量试验，测定空腹样本中黄体生成素、促卵泡激素（FSH）、性激素结合球蛋白、睾酮、雄烯二酮（A4）、17 α -羟孕酮（17- ohp）和AMH的循环浓度。结果：在Tanner II-III期，pcos组的腰臀比、FSH和雄烯二酮水平明显高于对照组。在Tanner II-III期和IV-V期，pcos患者总胆固醇和LDL水平明显升高。倾向评分分析显示，较高的LDL水平可归因于pcos状况，而不是其他代谢因素。所有阶段的AMH水平具有可比性。其余参数在两组之间具有可比性。结论：多囊卵巢综合征女性的儿子在青春期表现出总胆固醇和低密度脂蛋白水平升高，这可能代表潜在的胰岛素抵抗。因此，这是一个应该跟踪和研究的群体，寻找胰岛素抵抗和心血管危险标志物的进一步特征。另一方面，生殖标记与对照非常相似。
Context: Intrauterine life may be implicated in the origin of polycystic ovary syndrome (PCOS) modifying the endocrine and metabolic functions of children born to PCOS mothers independently of the genetic inheritance and gender. The aim of the present study was to evaluate the reproductive and metabolic functions in sons of women with PCOS during puberty.Methods: Sixty-nine PCOS sons (PCOSs) and 84 control sons of 7-18 years old matched by the Tanner stage score were studied. A complete physical examination was conducted including anthropometric measurements (weight, height, waist, hip and body mass index). An oral glucose tolerance test was performed and circulating concentrations of luteinizing hormone, follicle-stimulating hormone (FSH), sex hormone-binding globulin, testosterone, androstenedione (A4), 17 alpha-hydroxyprogesterone (17-OHP) and AMH were determined in the fasting sample.Results: Waist-to-hip ratio, FSH and androstenedione levels were significantly higher in the PCOSs group compared to control boys during the Tanner stage II-III. In Tanner stages II-III and IV-V, PCOSs showed significantly higher total cholesterol and LDL levels. Propensity score analysis showed that higher LDL levels were attributable to the PCOSs condition and not to other metabolic factors. AMH levels were comparable during all stages. The rest of the parameters were comparable between both groups.Conclusions: Sons of women with PCOS show increased total cholesterol and LDL levels during puberty, which may represent latent insulin resistance. Thus, this is a group that should be followed and studied looking for further features of insulin resistance and cardiovascular risk markers. Reproductive markers, on the other hand, are very similar to controls.