Prenatal and childhood adverse life events, inflammation and depressive symptoms across adolescence
Prenatal and childhood adverse life events, inflammation and depressive symptoms across adolescence
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DOI：
10.1016/j.jad.2019.09.024
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发表时间：
2020-01-01
影响因子：
6.6
通讯作者：
Lewis, Glyn
中科院分区：
文献类型：
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作者：
Flouri, Eirini;Francesconi, Marta;Lewis, Glyn
背景：没有研究调查炎症在解释早期不良生活事件暴露与青春期抑郁症状之间的关系中的作用。方法：使用雅芳父母和儿童纵向研究的数据，我们测试了9岁时的炎症标志物[血清c -反应蛋白（CRP）和白细胞介素6 (IL-6)]是否介导了不良生活事件之间的关联，分别在产前（怀孕开始）和童年（0-9岁）期间测量，以及10-17岁时抑郁症状的发展。数据（n = 4,263）在潜在生长曲线建模框架中使用中介分析进行分析。结果：青春期初期（10岁）的抑郁症状与产前事件的数量、出生前后事件的数量以及儿童期（0-9岁）随着时间的推移事件的增加有关，即使在调整了混杂因素之后也是如此。随着时间的推移，IL-6在儿童时期暴露于事件的增加与青春期开始时抑郁症状之间的关联中起到部分介导作用。IL-6没有介导事件和症状之间的任何其他关联。没有证据表明CRP有中介作用，这通常与暴露于事件无关。局限性：中介效应的小规模和产前和出生前后事件的强大直接影响表明，从早期压力源到青少年抑郁有多种途径。结论：在一般青少年人群中，随着时间的推移，儿童时期不断增加的社会心理压力源暴露与抑郁症状的早期发作有关，部分原因是血浆IL-6水平升高。
Background: No study has investigated the role of inflammation in explaining the association between early exposures to adverse life events and depressive symptoms in adolescence.Method: Using data from the Avon Longitudinal Study of Parents and Children, we tested if inflammatory markers [serum C-reactive protein (CRP) and interleukin 6 (IL-6)] at age 9 years mediate the association between adverse life events, measured separately for the prenatal (since the beginning of pregnancy) and the childhood (ages 0-9 years) periods, and the development of depressive symptoms at ages 10-17 years. Data (n = 4,263) were analyzed using mediation analysis in a latent growth curve modeling framework.Results: Depressive symptoms at the beginning of adolescence (age 10) were associated with the number of prenatal events, the number of events around birth and the increase in events over time in childhood (ages 0-9), even after adjustment for confounders. IL-6 partially mediated the association between increasing exposure to events over time in childhood and depressive symptoms at the beginning of adolescence. IL-6 did not mediate any other association between events and symptoms. There was no evidence for mediation by CRP, which was generally unrelated to exposure to events.Limitations: The small size of the mediation effect and the robust direct effects of events prenatally and around birth suggest there are multiple routes from early stressors to adolescent depression.Conclusions: In the general adolescent population, increasing exposure to psychosocial stressors over time during childhood is associated with the early onset of depressive symptoms, partly via increasing levels of plasma IL-6.