Therapeutic approaches to inflammation in neurodegenerative disease
Therapeutic approaches to inflammation in neurodegenerative disease
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DOI：
10.1097/wco.0b013e3280adc943
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发表时间：
2007-06-01
影响因子：
4.8
通讯作者：
McGeer, Patrick L.
中科院分区：
文献类型：
--
作者：
Klegeris, Andis;McGeer, Edith G.;McGeer, Patrick L.
综述目的根据神经退行性疾病的神经炎症假说，具有抗炎作用模式的药物应减缓疾病进展。在这里，我们回顾了最近的进展，在我们的理解这样的疾病，帕金森氏病，其中抗炎药物现在正成为一个新的治疗focus.Recent的发现帕金森氏病的炎症机制的参与已被揭示通过在体外和体内的实验研究支持的病理和流行病学的结果。一些已证实的炎症机制与其他神经退行性疾病相同，但也出现了一些帕金森病特异性机制。这些包括炎症刺激的相互作用的α-突触核蛋白与小胶质细胞和星形胶质细胞和抑制作用的非甾体类抗炎药对多巴胺醌formation.Summary可以预期，更详细地了解帕金森氏病的神经炎症机制将导致新的细胞和分子靶点，这可能反过来，允许设计帕金森氏病修饰药物。未来的治疗可能涉及针对炎症和非炎症机制的药物联合治疗。
Purpose of review According to the neuroinflammatory hypothesis of neurodegenerative diseases, drugs with an anti-inflammatory mode of action should slow the disease progression. Here we review recent advances in our understanding of one such disorder, Parkinson's disease, in which anti-inflammatory drugs are now becoming a new therapeutic focus.Recent findings The involvement of inflammatory mechanisms in Parkinson's disease has been revealed through in-vitro and in-vivo experimental studies supported by pathological and epidemiological findings. Several of the demonstrated inflammatory mechanisms are shared by other neurodegenerative disorders but some Parkinson's disease-specific mechanisms have also emerged. These include inflammatory stimulation by interaction of alpha-synuclein with microglia and astrocytes and a suppressive action by nonsteroidal anti-inflammatory drugs on dopamine quinone formation.Summary It can be anticipated that a more detailed understanding of neuroinflammatory mechanisms in Parkinson's disease will lead to new cellular and molecular targets, which may, in turn, permit design of Parkinson's disease modifying drugs. Future treatment may involve combination therapies with drugs directed at both inflammatory and non-inflammatory mechanisms.