Role of T-type Ca2+ Channels in the Spontaneous Phasic Contraction of Pregnant Rat Uterine Smooth Muscle
Role of T-type Ca2+ Channels in the Spontaneous Phasic Contraction of Pregnant Rat Uterine Smooth Muscle
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DOI：
10.4196/kjpp.2009.13.3.241
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发表时间：
2009-06-01
影响因子：
2
通讯作者：
Lee, Young-Ho
中科院分区：
文献类型：
--
作者：
Lee, Si-Eun;Ahn, Duck-Sun;Lee, Young-Ho
虽然细胞外Ca 2+通过电压依赖性Ca 2+通道进入妊娠大鼠子宫肌层的自发性阶段性收缩中起着重要作用，T型Ca 2+通道的作用尚未完全确定。本研究的目的是探讨T型钙通道在大鼠子宫肌层自发性阶段性收缩中的作用。在妊娠晚期（妊娠第18天与第20天相似：足月=22天）的雌性Sprague-Dawley大鼠纵条中同时测量自发阶段性收缩和[Ca 2 +]（i）。测定T型钙通道mRNA或蛋白水平的表达。低浓度的累积添加（
Although extracellular Ca2+ entry through the voltage-dependent Ca2+ channels plays an important role in the spontaneous phasic contractions of the pregnant rat myometrium, the role of the T-type Ca2+ channels has yet to be fully identified. The aim of this study was to investigate the role of the T-type Ca2+ channel in the spontaneous phasic contractions of the rat myometrium. Spontaneous phasic contractions and [Ca2+](i) were measured simultaneously in the longitudinal strips of female Sprague-Dawley rats late in their pregnancy (on day 18 similar to 20 of gestation: term=22 days). The expression of T-type Ca2+ channel mRNAs or protein levels was measured. Cumulative addition of low concentrations (