Inhibitors of α-amylase and α-glucosidase from Andromachia igniaria Humb. & Bonpl.
Inhibitors of α-amylase and α-glucosidase from Andromachia igniaria Humb. & Bonpl.
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DOI：
10.1016/j.phytol.2015.08.018
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发表时间：
2015-12
影响因子：
1.7
通讯作者：
M. B. V. Saltos;Blanca Fabiola Naranjo Puente;I. Faraone;L. Milella;N. Tommasi;A. Braca
中科院分区：
文献类型：
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作者：
M. B. V. Saltos;Blanca Fabiola Naranjo Puente;I. Faraone;L. Milella;N. Tommasi;A. Braca
从穿心莲的部分提取物中分离得到两个新的黄酮类化合物：(2S)-3‘，4’，7，8-四羟基黄烷酮7-O-(6“-O-乙酰基)-β-d-吡喃葡萄糖苷(1)和3‘，4’，7，8-四羟基黄酮7-O-(6”-O-乙酰基)-β-d-吡喃葡萄糖苷(2)，以及14个已知化合物。它们的结构通过包括2D核磁共振在内的波谱分析确定。通过测定α-淀粉酶和α-葡萄糖苷酶的抑制作用，评价了所有提取物和纯化合物的降血糖性能。其中正丁醇对α-淀粉酶和α-葡萄糖苷酶的抑制效果最好，而化合物中活性最强的化合物是：木犀草素和木犀草素4‘-O-β-d-吡喃葡萄糖苷作为α-淀粉酶的抑制剂，芥子醇、丁黄素和欧甘宁作为α-葡萄糖苷酶的抑制剂。结果表明，这一点是正确的。木香多糖是一种重要的天然来源，具有很高的生物学价值，有助于控制餐后低血糖。
Two new flavonoids, (2S)-3’,4’,7,8-tetrahydroxyflavanone 7-O-(6”-O-acetyl)-β-d-glucopyranoside (1) and 3’,4’,7,8-tetrahydroxyflavone 7-O-(6”-O-acetyl)-β-d-glucopyranoside (2) along with fourteen known compounds were isolated fromAndromachia igniariaaerial part extracts. Their structures were determined via spectroscopic analyses including 2D NMR. The hypoglycemic properties of all extracts and pure compounds were evaluated measuring α-amylase and α-glucosidase inhibitory effects. Then-butanol among the extracts was found to be the best inhibitor of both α-amylase and α-glucosidase enzymes, while among compounds the most active were: bidenoside F and luteolin 4’-O-β-d-glucopyranoside as α-amylase inhibitors; eriodictyol, butein and okanin as α-glucosidase inhibitors. Results demonstrated thatA. igniariacan represent an important natural source with high biological values, helpful to control postprandial hypoglycemia.