Is procedural memory relatively spared from age effects?
Is procedural memory relatively spared from age effects?
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DOI：
10.1016/s0197-4580(02)00194-x
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发表时间：
2003-10-01
影响因子：
4.2
通讯作者：
Greenough, WT
中科院分区：
文献类型：
--
作者：
Churchill, JD;Stanis, JJ;Greenough, WT
许多类型的与年龄相关的神经系统缺陷已被充分记录。虽然容易受到年老影响的一般记忆类型之间的区别已得到相当一致的认可，但通常很难准确确定哪些特定过程受到不利影响。在这项研究中，我们使用了一种范式，使我们能够区分与粗大运动缺陷相关的影响和由于运动技能本身的学习和记忆而产生的影响。就潜伏期和错误而言，与年轻动物相比，衰老动物穿越高架障碍物的能力平均受损。然而，如果考虑到大运动能力，这些缺陷的一小部分就很容易解释。此外，如果个体基线表现差异标准化，则不同年龄组之间的记忆力差异不明显。这些观察结果表明，程序性任务的记忆不会随着年龄的增长而受损。 (C) 2002 Elsevier Science Inc. 保留所有权利。
Numerous types of age-related deficits in the nervous system have been well documented. While a distinction between general types of memories that are susceptible to compromise with advanced age has been fairly well agreed upon, it is often difficult to determine exactly which specific processes are detrimentally influenced. In this study, we used a paradigm that enabled us to distinguish between effects associated with gross motor deficits and those due to learning and memory of a motor skill, per se. In terms of both latency and errors, senescent animals were, on average, impaired in their ability to traverse an elevated obstacle course, compared to younger animals. Yet, if gross motor abilities are accounted for, a fraction of these deficits is readily explained. Moreover, if individual baseline performance differences are normalized, no memory differences are evident across age groups. These observations suggest that memory for a procedural task is not impaired with advanced age. (C) 2002 Elsevier Science Inc. All rights reserved.