Room-Temperature-Formed PEDOT:PSS Hydrogels Enable Injectable, Soft, and Healable Organic Bioelectronics
Room-Temperature-Formed PEDOT:PSS Hydrogels Enable Injectable, Soft, and Healable Organic Bioelectronics
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DOI：
10.1002/adma.201904752
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发表时间：
2019-10-28
影响因子：
29.4
通讯作者：
Khademhosseini, Ali
中科院分区：
文献类型：
--
作者：
Zhang, Shiming;Chen, Yihang;Khademhosseini, Ali
开发用于生物电子应用的导电水凝胶的需求日益增加。特别是聚（3,4-乙烯二氧噻吩）：聚（苯乙烯磺酸酯）（PEDOT:PSS）水凝胶因其优异的生物相容性和稳定性而成为研究热点。然而，可注射的PEDOT:PSS水凝胶很少有报道。这种可注射的水凝胶对于微创生物医学治疗是非常理想的。本文介绍了利用PEDOT:PSS的室温凝胶特性制备可注射型PEDOT:PSS水凝胶的方法。这些PEDOT:PSS水凝胶在注射器注射到所需位置后自发形成，无需任何额外的处理。提出了一种在室温下大规模生产可注射PEDOT:PSS水凝胶纤维的简便策略。最后，证明了这些室温形成的PEDOT:PSS水凝胶（RT-PEDOT:PSS水凝胶）和水凝胶纤维可用于开发柔软且自愈的水凝胶生物电子器件。
There is an increasing need to develop conducting hydrogels for bioelectronic applications. In particular, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) hydrogels have become a research hotspot due to their excellent biocompatibility and stability. However, injectable PEDOT:PSS hydrogels have been rarely reported. Such syringe-injectable hydrogels are highly desirable for minimally invasive biomedical therapeutics. Here, an approach is demonstrated to develop injectable PEDOT:PSS hydrogels by taking advantage of the room-temperature gelation property of PEDOT:PSS. These PEDOT:PSS hydrogels form spontaneously after syringe-injection into the desired location, without the need of any additional treatments. A facile strategy is also presented for large-scale production of injectable PEDOT:PSS hydrogel fibers at room temperature. Finally, it is demonstrated that these room-temperature-formed PEDOT:PSS hydrogels (RT-PEDOT:PSS hydrogel) and hydrogel fibers can be used for the development of soft and self-healable hydrogel bioelectronic devices.