Simultaneous synthesis of treatment effects and mapping to a common scale: an alternative to standardisation.
Simultaneous synthesis of treatment effects and mapping to a common scale: an alternative to standardisation.
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DOI：
10.1002/jrsm.1130
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发表时间：
2015-03
影响因子：
9.8
通讯作者：
Kounali, Daphne
中科院分区：
文献类型：
--
作者：
Ades, A. E.;Lu, Guobing;Dias, Sofia;Mayo-Wilson, Evan;Kounali, Daphne
试验通常可能报告在不同测试仪器上测量的几个类似结果。我们探索了一种方法，用于在试验内和试验之间合成治疗效果信息，并在通用量表上报告治疗效果，作为标准化的替代方案。我们应用了一种程序，该程序同时估计合并治疗效果和连接网络中测试仪器上治疗效果之间的“映射”比率。比较了标准化和非标准化治疗效果。这些方法在22项选择性5-羟色胺再摄取抑制剂与安慰剂治疗社交焦虑障碍的试验数据集中得到了说明，每项试验都报告了对总共9种测试仪器中的1至6种的治疗效果。不同测试仪器的治疗效果比例因试验而异，变异系数为18%（95%可信区间11-29%）。标准化效应模型与数据的拟合较差，估计标准化治疗效应的相对精密度低于非标准化效应，且相对异质性较大。同时合成治疗效应并映射到一个通用量表，比通过将效应除以样本标准差进行标准化所做的假设更少，允许在通用量表上报告结果，并提供具有上级相对精度的估计值。版权所有© 2015作者.由John Wiley & Sons，Ltd.出版的研究合成方法。
Trials often may report several similar outcomes measured on different test instruments. We explored a method for synthesising treatment effect information both within and between trials and for reporting treatment effects on a common scale as an alternative to standardisation We applied a procedure that simultaneously estimates a pooled treatment effect and the “mapping” ratios between the treatment effects on test instruments in a connected network. Standardised and non-standardised treatment effects were compared. The methods were illustrated in a dataset of 22 trials of selective serotonin reuptake inhibitors against placebo for social anxiety disorder, each reporting treatment effects on between one and six of a total nine test instruments. Ratios of treatment effects on different test instruments varied from trial to trial, with a coefficient of variation of 18% (95% credible interval 11–29%). Standardised effect models fitted the data less well, and standardised treatment effects were estimated with less relative precision than non-standardised effects and with greater relative heterogeneity. Simultaneous synthesis of treatment effects and mapping to a common scale make fewer assumptions than standardising by dividing effects by the sample standard deviation, allow results to be reported on a common scale, and deliver estimates with superior relative precision. © 2015 The Authors. Research Synthesis Methods published by John Wiley & Sons, Ltd.
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影响因子：
6.9
作者：
Davidson, JRT;Miner, CM;Potts, NLS
通讯作者：
Potts, NLS
影响因子：
2.4
作者：
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作者：
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通讯作者：
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影响因子：
4.1
作者：
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通讯作者：
Hofmann, SG