Clinical aspects of gastrointestinal mucus.
Clinical aspects of gastrointestinal mucus.
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胃肠粘液的临床方面。
DOI：
10.1007/978-1-4615-9254-9_32
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发表时间：
1982
影响因子：
--
通讯作者：
J. Forstner
中科院分区：
文献类型：
--
作者：
G. Forstner;A. Wesley;J. Forstner
在这样一个鸟瞰一个非常复杂和复杂的文学是不可避免的重大贡献，特别是从早期的调查，将被忽视。然而，我们已努力为将在这次会议上进行的许多发言和讨论提供一个合理的框架。与过去一样，显然需要做很多工作来协调许多疾病中胃肠粘液的出色组织化学研究与粘蛋白结构和组成的日益增加的知识。这只能通过从患病肠中提取高纯度粘蛋白来实现。在这方面，死后的材料提供了一个机会，粘蛋白的研究人员是不提供给其他领域的工作人员，因为相对自由的分解。粘蛋白技术与免疫学的结合也是一个主要的优先事项。免疫分析技术为分泌研究中快速准确的产品鉴定提供了答案。特异性单克隆抗体将为复杂混合物中抗原的结构分化提供途径。同样明显的是，我们必须寻求开发各种可控模型，用于研究生理条件下粘液的功能参数、寄生虫排斥、肿瘤形成和炎症状态。这次审查中提到了一些有希望的倡议，但这些倡议必须仅仅是开始。然而，最后我们必须承认，自1976年的上次会议以来，知识的进步确实令人瞩目。我们可以感觉到，有一天打开这个“定义不清”的王国大门的钥匙，有些已经在手中，而其余的至少是触手可及的。
In such a bird's eye view of a very complicated and complex literature it is inevitable that significant contributions, particularly from earlier investigators, will have been overlooked. We have tried, however, to provide a reasonable framework for the many presentations and discussions which will take place at this conference. As in the past, it is evident that much needs to be done to reconcile the excellent histochemical studies of gastrointestinal mucus in many diseases with the increasing knowledge of mucin structure and composition. This will only be achieved by extraction of highly pure mucin from diseased bowel. In this regard, post mortem material provides an opportunity for mucin researchers which is not available to workers in other fields because of relative freedom from decomposition. The wedding of mucin technology with immunology is also a major priority. Immunoassay techniques provide the answer to quick and accurate product identification in secretion studies. Specific monoclonal antibodies will provide the route to structural differentiation of antigens in complex mixtures. It is also evident that we must seek to develop a variety of controllable models for the study of functional parameters of mucus in physiological conditions, parasite rejection, neoplasia and inflammatory states. Promising initiatives have been touched upon in this review, but these must only be the beginning. One must conclude, however, by recognizing that advances in knowledge have been truly remarkable since the last conference in 1976. One senses that some of the keys which will one day unlock the gates of this "ill-defined" kingdom are already in hand, while the remainder are at least within reach.
从大鼠结肠粘液糖蛋白中分离和表征寡糖。
DOI：
--
发表时间：
1980
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Slomiany,BL;Murty,VL;Slomiany,A
通讯作者：
Slomiany,A