Abnormalities of thalamic volume and shape in schizophrenia
Abnormalities of thalamic volume and shape in schizophrenia
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DOI：
10.1176/appi.ajp.161.5.896
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发表时间：
2004-05-01
影响因子：
17.7
通讯作者：
Miller, MI
中科院分区：
文献类型：
--
作者：
Csernansky, JG;Schindler, MK;Miller, MI
目的：精神分裂症的尸检和神经影像学研究已报道丘脑及其组成核团体积存在缺陷。然而，与这种体积损失相关的形状变化模式尚未得到研究。在本研究中，对患有和未患有精神分裂症的受试者的丘脑体积、形状和对称性的改变进行了比较。
方法：收集了52名精神分裂症患者和65名在年龄、性别、种族和父母社会经济地位相匹配的对照受试者的T1加权磁共振扫描图像。使用高维（大变形）脑映射来评估丘脑形态。
结果：在精神分裂症受试者中发现丘脑体积存在显著差异，丘脑结构前后两端的形状畸形，以及丘脑不对称性显著增大（即左侧小于右侧）。在对全脑体积进行协变量分析后，丘脑体积的差异变得不显著。当把丘脑形状信息与先前收集的海马形状信息相结合时，精神分裂症患者和对照受试者之间的区分度得到提高。
结论：精神分裂症患者的丘脑体积比正常人小，但仅与全脑体积的减少成比例。丘脑形状和不对称性的改变表明丘脑复合体前后两端的单个核团有更严重的病理累及。
Objective: Postmortem and neuroimaging studies of schizophrenia have reported deficits in the volume of the thalamus and its component nuclei. However, the pattern of shape change associated with such volume loss has not been investigated. In this study, alterations in thalamic volume, shape, and symmetry were compared in subjects with and without schizophrenia.Method: T-1-weighted magnetic resonance scans were collected in 52 schizophrenia and 65 comparison subjects matched for age, gender, race, and parental socioeconomic status. High-dimensional (large-deformation) brain mapping was used to assess thalamic morphology.Results: Significant differences in thalamic volume, deformities of thalamic shape at the anterior and posterior extremes of the structure, and a significant exaggeration of thalamic asymmetry (i.e., left smaller than right) were found in the schizophrenia subjects. After covarying for total cerebral volume, the difference in thalamic volume became insignificant. When information about thalamic shape was combined with previously collected information about hippocampal shape, the discrimination between schizophrenia patients and comparison subjects was improved.Conclusions: Thalamic volume was smaller than normal in schizophrenia patients, but only proportionate to reductions in reduced total cerebral volume. The presence of changes in thalamic shape and asymmetry suggest greater pathologic involvement of individual nuclei at its anterior and posterior extremes of the thalamic complex.