High expression of COX5B is associated with poor prognosis in breast cancer
High expression of COX5B is associated with poor prognosis in breast cancer
复制标题
COX5B高表达与乳腺癌不良预后相关
DOI：
10.2217/fon-2017-0058
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发表时间：
2017-08-01
期刊：
影响因子：
3.3
通讯作者：
Jin, Wei
中科院分区：
文献类型：
--
作者：
Gao, Shui-Ping;Sun, He-Fen;Jin, Wei
背景：细胞色素c氧化酶亚基VB（COX 5 B）是哺乳动物考克斯的一个亚基，参与考克斯的组装和功能。在线数据库预测高COX5B转录可能与更差的无病生存率（DFS）相关。然而，COX5B在乳腺癌中的临床意义仍不清楚。方法：应用免疫组织化学方法检测244例乳腺浸润性导管癌组织芯片中COX 5B的表达。结果：COX 5B蛋白表达水平与肿瘤大小有关。COX5B过表达提示乳腺癌的DFS更差（p < 0.05）。COX5B高表达可能是乳腺癌DFS恶化的独立因素。结论：累积起来，我们的研究结果表明，COX 5B可能作为一个重要的乳腺癌预后因素。
Background: Cytochrome c oxidase subunit VB (COX5B), a subunit of mammalian COX, takes roles in COX assembling and functions. Online database predicts high COX5B transcription may be associated with worse disease-free survival (DFS). However, the clinical implications of COX5B in breast cancer remain unclear. Methods: We carried out immunohistochemistry on tissue microarrays of 244 patients with invasive ductal breast carcinoma to detected COX5B expression. Results: Our results suggest that COX5B protein level might be associated with tumor size. COX5B overexpression indicated a worse DFS (p < 0.05) in breast cancer. Furthermore, high COX5B expression may act as an independent factor for worse DFS in breast cancer. Conclusions: Cumulatively, our findings suggest that COX5B might serve as an important prognostic factor for breast cancer.