Simulations of pertussis epidemiology in the United States: effects of adult booster vaccinations
Simulations of pertussis epidemiology in the United States: effects of adult booster vaccinations
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DOI：
10.1016/s0025-5564(99)00004-8
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发表时间：
1999-04-01
影响因子：
4.3
通讯作者：
Hethcote, HW
中科院分区：
文献类型：
--
作者：
Hethcote, HW
一个扩大的百日咳（百日咳）疫苗接种计划，其中包括成人助推器每10年使用两个模型的计算机模拟研究。这些年龄结构的百日咳传播模式包括感染获得性免疫和疫苗诱导免疫的减弱，以及与1940年以来的疫苗接种覆盖率相对应的儿童接种。第二种模型中成人接种疫苗比第一种模型中的免疫水平提高更大。在模拟中，每10年增加一次成人百日咳加强疫苗接种有利于降低成人发病率，但仅导致婴儿和幼儿发病率的适度降低。这些模拟表明，在实施成人百日咳疫苗接种计划之前，需要进行仔细的成本效益分析。(C)1999年由Elsevier Science Inc.出版All rights reserved.
An expanded pertussis (whooping cough) vaccination program which includes adult boosters every 10 yr is studied using computer simulations of two models. These age-structured pertussis transmission models include waning of both infection-acquired and vaccine-induced immunity, and vaccination of children corresponding to the vaccination coverage since 1940. Adult vaccinations cause a larger boost in the immunity level in the second model than in the first model. In the simulations the addition of adult pertussis booster vaccinations every 10 yr is beneficial in reducing adult incidence, but causes only modest reductions in the incidence in infants and young children. These simulations suggest that a careful cost effectiveness analysis is needed before implementation of an adult pertussis vaccination program. (C) 1999 Published by Elsevier Science Inc. All rights reserved.