Radiographic evidence of prominent retro and suborbicularis oculi fat in thyroid-associated orbitopathy
Radiographic evidence of prominent retro and suborbicularis oculi fat in thyroid-associated orbitopathy
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DOI：
10.3109/01676830.2015.1099689
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Nunery, William R.
中科院分区：
文献类型：
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作者：
Thornton, Ivey L.;Clark, Jeremy;Nunery, William R.
目的：比较甲状腺相关性眼眶病（TAO）患者和正常人眼轮匝肌后脂肪（ROOF）和眼轮匝肌下脂肪（SOOF）的放射学差异，使用CT（CT）。方法：回顾性分析眼眶CT在39例连续患者中进行，他们在2005年10月和2009年6月之间成像。对16例甲状腺眼眶病变患者和23例正常人的双侧眼眶CT进行了评价。所有CT均由0.75 mm厚的轴向切片和1.5 mm冠状面重建组成。使用轴向软组织窗口，识别ROOF和SOOF组织。垂直于额骨测量最大顶部厚度，紧邻眶上缘的上级。同样，垂直于颧骨测量SOOF的最大厚度，紧邻眶下缘的下外侧。在进行测量时，放射科医生对CT报告不知情。结果：16例TAO患者和23例非TAO患者共获得78个ROOF和SOOF测量值。TAO组的男女比例为6：1，而正常组仅为3：2。TAO患者的平均轴向ROOF厚度为3.8 +/- 1.9 mm，无TAO患者为2.8 +/- 1.0 mm，而两组的SOOF厚度分别为4.4 +/- 1.0 mm和3.4 +/- 1.0 mm。为了解释双侧测量，使用了混合模型分析。在控制年龄、性别和种族后，TAO ROOF和SOOF的平均厚度为1.0 mm（p = 0.04）和0.9 mm（p < 0.01）分别大于对照组。眼轮匝肌后脂肪（ROOF）和眼轮匝肌下脂肪（SOOF）肥大是两个额外的放射学CT测量，可能对甲状腺疾病的诊断有价值。相关眼眶病
Purpose: To compare the radiological differences in retro-orbicularis oculi fat (ROOF) and suborbiculars oculi fat (SOOF) among patients with thyroid-associated orbitopathy (TAO) and normal subjects using computed tomography (CT).Methods: A retrospective analysis of orbital CTs was performed in 39 consecutive patients, who were imaged between October 2005 and June 2009. Bilateral orbital CTs of 16 patients with a final report significant for thyroid orbitopathy and 23 normal subjects were evaluated. All of the CTs consisted of 0.75 mm thick axial slices with 1.5 mm coronal reconstructions. Using the axial soft tissue windows, the ROOF and SOOF tissues were identified. The maximum ROOF thickness was measured perpendicular to the frontal bone, immediately superior to the supraorbital rim. Similarly, the maximum SOOF thickness was measured perpendicular to the zygomatic bone, immediately inferolateral to the infraorbital rim. The radiologist was blinded to the CT reports while conducting the measurements. Multivariable analysis of the two groups was then performed for comparison.Results: Seventy-eight ROOF and SOOF measurements were obtained from 16 TAO patients with and 23 patients without TAO. The female-to-male ratio was 6: 1 in the TAO group and only 3: 2 among the normal subjects. The mean axial ROOF thicknesses was 3.8 +/- 1.9 for TAO patients and 2.8 +/- 1.0 mm in patients without TAO, while the SOOF thickness was 4.4 +/- 1.0 and 3.4 +/- 1.0 mm in the 2 groups, respectively. To account for bilateral measurements, the mixed model analysis was used. After controlling for age, gender, and ethnicity, the mean TAO ROOF and SOOF thicknesses were 1.0 mm (p = 0.04) and 0.9 mm (p < 0.01) greater than the control group, respectively.Conclusion: Retro-orbicularis oculi fat (ROOF) and suborbicularis oculi fat (SOOF) hypertrophy are two additional radiologic CT measurements that may be valuable in establishing the diagnosis of thyroid-associated orbitopathy.