Population-based study of the incidence of sudden unexplained death in epilepsy
Population-based study of the incidence of sudden unexplained death in epilepsy
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DOI：
10.1212/wnl.51.5.1270
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发表时间：
1998-11-01
期刊：
影响因子：
9.9
通讯作者：
Belau, PG
中科院分区：
文献类型：
--
作者：
Ficker, DM;So, EL;Belau, PG
目的：确定癫痫不明原因猝死（SUDEP）的人群发病率，并确定与普通人群相比SUDEP的风险背景：以前的SUDEP研究描述了广泛的发病率，并受到选择偏倚和其他方法学限制。从未进行过基于人群的SUDEP发病率研究。此外，癫痫人群的猝死风险尚未与普通人群进行比较。方法：回顾了1935年至1994年在明尼苏达州罗切斯特诊断为癫痫的所有死亡病例。将SUDEP发生率与一般人群中20 - 40岁患者的预期猝死发生率进行比较，以确定标准化死亡率（SMR）。结果：我们确定了9例SUDEP。SUDEP占15至44岁人群死亡人数的8.6%（81人中有7人）。SUDEP的发生率为0.35/1000人-年。与一般人群相比，SUDEP的SMR为23.7（95%置信区间，7.7 - 55.0）。结论：在我们的研究中，SUDEP的发生率为0.35/1000人-年。在我们的队列中，SUDEP占死亡人数的1.7%。SUDEP是癫痫人群中罕见的死亡原因，但超过了一般人群中预期的猝死率近24倍。
Objective: To determine the population-based incidence of sudden unexplained death in epilepsy (SUDEP) and to determine the risk of SUDEP compared with the general population Background: Prior studies of SUDEP have described a wide range of incidence and have suffered from selection bias and other methodologic limitations. A population-based study of the incidence of SUDEP has never been performed. Furthermore, the risk of sudden death in the epilepsy population has not been compared with that of the general population. Methods: All deaths in persons whose epilepsy was diagnosed between 1935 and 1994 in Rochester, MN, were reviewed. The rate of SUDEP was compared with the expected rate of sudden death in the general population for patients age 20 to 40 years to determine the standardized mortality ratio (SMR). Results: We identified nine cases of SUDEP. SUDEP accounted for 8.6% (7 of 81) of the deaths in persons 15 to 44 years of age. The incidence of SUDEP was 0.35 per 1,000 person-years. SMR for SUDEP was 23.7 (95% confidence interval, 7.7 to 55.0) compared with the general population. Conclusions: The incidence of SUDEP in our study was 0.35 per 1,000 person-years. SUDEP was responsible for 1.7% of deaths in our cohort. SUDEP is a rare cause of death in the epilepsy population but exceeds the expected rate of sudden death in the general population by nearly 24 times.