Apolipoprotein E4 as a predictor of outcomes in pediatric mild traumatic brain injury.
Apolipoprotein E4 as a predictor of outcomes in pediatric mild traumatic brain injury.
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载脂蛋白 E4 作为儿科轻度创伤性脑损伤结果的预测因子。
DOI：
10.1089/neu.2008.0767
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发表时间：
2009
影响因子：
4.2
通讯作者：
Yeates,KeithO
中科院分区：
文献类型：
--
作者：
Moran,LisaM;Taylor,HGerry;Ganesalingam,Kalaichelvi;Gastier-Foster,JulieM;Frick,Jessica;Bangert,Barbara;Dietrich,Ann;Nuss,KathrynE;Rusin,Jerome;Wright,Martha;Yeates,KeithO
载脂蛋白E（APOE）基因的α 4等位基因与成人创伤性脑损伤（TBI）严重程度的负面结果有关，初步证据表明儿童中存在类似模式。本研究调查了轻度TBI患儿APOE β 4等位基因与预后的关系。这项前瞻性纵向研究的参与者包括99名8至15岁的轻度TBI儿童，他们是从两家大型儿童医院的急诊科连续入院招募的。在急诊科和伤后2周、3个月和12个月的随访中对结果进行了急性评估。在99名参与者中，28人至少有一个等位基因。携带和不携带α 4等位基因的儿童在人口统计学上没有差异。与没有等位基因的儿童相比，携带等位基因的儿童更有可能出现格拉斯哥昏迷量表评分低于15分的情况，但两组在损伤严重程度的任何其他指标上没有差异。在结构技能测试中，携带有等位基因的儿童表现出比没有等位基因的儿童更好的表现，但在其他神经心理学测试中，这两组儿童没有差异。有和没有等位基因的儿童在脑震荡后症状的测量上也没有差异。总的来说，研究结果表明，APOE β 4等位基因与儿童轻度TBI的结局并不一致。
The ɛ4 allele of the apolipoprotein E (APOE) gene has been linked to negative outcomes among adults with traumatic brain injury (TBI) across the spectrum of severity, with preliminary evidence suggesting a similar pattern among children. This study investigated the relationship of the APOE ɛ4 allele to outcomes in children with mild TBI. Participants in this prospective, longitudinal study included 99 children with mild TBI between the ages of 8 and 15 recruited from consecutive admissions to Emergency Departments at two large children's hospitals. Outcomes were assessed acutely in the Emergency Department and at follow-ups at 2 weeks, 3 months, and 12 months post-injury. Among the 99 participants, 28 had at least one ɛ4 allele. Children with and without an ɛ4 allele did not differ demographically. Children with an ɛ4 allele were significantly more likely than those without an ɛ4 allele to have a Glasgow Coma Scale score of less than 15, but the groups did not differ on any other measures of injury severity. Those with an ɛ4 allele exhibited better performance than children without an ɛ4 allele on a test of constructional skill, but the groups did not differ on any other neuropsychological tests. Children with and without an ɛ4 allele also did not differ on measures of post-concussive symptoms. Overall, the findings suggest that theAPOEɛ4 allele is not consistently related to the outcomes of mild TBI in children.