Hydrogels as a Replacement Material for Damaged Articular Hyaline Cartilage.
Hydrogels as a Replacement Material for Damaged Articular Hyaline Cartilage.
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DOI：
10.3390/ma9060443
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发表时间：
2016-06-03
期刊：
影响因子：
--
通讯作者：
Su B
中科院分区：
文献类型：
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作者：
Beddoes CM;Whitehouse MR;Briscoe WH;Su B
透明软骨是一种坚固耐用的材料，润滑关节运动。由于其无血管的结构，软骨具有较差的自我修复能力，因此，关节恢复具有挑战性。当软骨严重受损时，可能需要更换。然而，目前我们无法复制透明软骨，因此，使用具有相当不同性质的替代材料。这导致不期望的副作用，包括润滑不足、磨损碎屑、相对关节软骨的磨损以及周围组织的弱化。随着软骨修复手术数量的增加，对能够更好地模拟软骨并在其典型功能中支持周围材料的材料的需求变得越来越明显。在这里，我们提出了一个简单的概述的结构和性质的透明软骨和目前的软骨修复方法。然后，我们强调了一些正在开发的替代材料作为潜在的修复方法，其次是坚韧水凝胶的发展概述。特别是，双网络（DN）水凝胶是一种有前途的替代材料，具有不断改善的物理性能。这些水凝胶更接近于复制透明软骨的强度和韧性，同时提供出色的润滑。最后，我们强调了几种不同的方法，将替代材料与天然关节结合，以确保稳定性和最佳性能。
Hyaline cartilage is a strong durable material that lubricates joint movement. Due to its avascular structure, cartilage has a poor self-healing ability, thus, a challenge in joint recovery. When severely damaged, cartilage may need to be replaced. However, currently we are unable to replicate the hyaline cartilage, and as such, alternative materials with considerably different properties are used. This results in undesirable side effects, including inadequate lubrication, wear debris, wear of the opposing articular cartilage, and weakening of the surrounding tissue. With the number of surgeries for cartilage repair increasing, a need for materials that can better mimic cartilage, and support the surrounding material in its typical function, is becoming evident. Here, we present a brief overview of the structure and properties of the hyaline cartilage and the current methods for cartilage repair. We then highlight some of the alternative materials under development as potential methods of repair; this is followed by an overview of the development of tough hydrogels. In particular, double network (DN) hydrogels are a promising replacement material, with continually improving physical properties. These hydrogels are coming closer to replicating the strength and toughness of the hyaline cartilage, while offering excellent lubrication. We conclude by highlighting several different methods of integrating replacement materials with the native joint to ensure stability and optimal behaviour.