Minocycline Ameliorates Neuronal Loss after Pilocarpine-Induced Status epilepticus
Minocycline Ameliorates Neuronal Loss after Pilocarpine-Induced Status epilepticus
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发表时间：
2014
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通讯作者：
G. M. Arisi;M. L. Foresti;A. Montanez;Lee A. Shapiro
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作者：
G. M. Arisi;M. L. Foresti;A. Montanez;Lee A. Shapiro
二甲胺四环素是一种抗生素，在缺血、亨廷顿氏病和帕金森病的动物模型中显示出具有神经保护作用。然而，关于匹罗卡平诱导的癫痫持续状态后米诺环素治疗的神经保护作用的数据缺乏。在匹罗卡品诱导的SE发作后2小时给予25 mg/kg米诺环素。观察海马神经元丢失和小胶质细胞增殖情况。监测大鼠自发性反复发作的发展情况。发现二甲胺四环素治疗可减少癫痫引起的海马神经元损失。虽然二甲胺四环素治疗并没有显著抑制小胶质细胞的激活，但小胶质细胞数量的适度减少与更大的神经保护有关。最后，单剂量二甲胺四环素并不能预防自发性行为癫痫的发生。综上所述，研究结果表明米诺环素治疗对SE后的神经有保护作用。
Minocycline is an antibiotic agent that has been shown to have neuroprotective properties in animal models of ischemia, Huntington’s disease and Parkinson’s disease. However, data are lacking regarding the neuroprotective effects of minocycline treatment following pilocarpine-induced status epilepticus. Rats were treated with 25 mg/kg minocycline 2 hours after the onset of pilocarpine-induced SE. The hippocampus was examined for neuronal loss and microglia proliferation. The rats were monitored for the development of spontaneous recurrent seizures. Minocycline treatment was found to reduce seizure-induced neuronal loss in the hippocampus. Although minocycline treatment did not significantly inhibit microglia activation, a modest reduction in microglial cell number was related to greater neuroprotection. Finally, a single-dose of minocycline did not prevent the occurrence of spontaneous behavioral seizures. Taken together, the findings suggest that Minocycline treatment is neuroprotective after SE.