Biological embedding of experience: A primer on epigenetics
Biological embedding of experience: A primer on epigenetics
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DOI：
10.1073/pnas.1820838116
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发表时间：
2020-09-22
影响因子：
11.1
通讯作者：
O'Donnell, Kieran J.
中科院分区：
文献类型：
--
作者：
Aristizabal, Maria J.;Anreiter, Ina;O'Donnell, Kieran J.
当生活经历改变生物过程从而影响以后的生活健康和福祉时，就会发生生物嵌入。尽管存在大量相关数据支持表观遗传机制（如DNA甲基化）是生物嵌入的基础，但缺乏因果数据。我们描述了具体的表观遗传机制及其在经验的生物嵌入中的潜在作用。我们还考虑了基因组、表观基因组和基因表达之间的微妙关系。由于多种因素的影响，我们将生物嵌入与复杂的表观遗传景观联系起来的能力具有挑战性和复杂性。这些因素包括细胞类型、年龄、经历的时间、性别和DNA序列。分子分析和表观基因组编辑的最新进展，结合动物和人类纵向比较研究的使用，应该使该领域从相关分析过渡到因果分析。
Biological embedding occurs when life experience alters biological processes to affect later life health and well-being. Although extensive correlative data exist supporting the notion that epigenetic mechanisms such as DNA methylation underlie biological embedding, causal data are lacking. We describe specific epigenetic mechanisms and their potential roles in the biological embedding of experience. We also consider the nuanced relationships between the genome, the epigenome, and gene expression. Our ability to connect biological embedding to the epigenetic landscape in its complexity is challenging and complicated by the influence of multiple factors. These include cell type, age, the timing of experience, sex, and DNA sequence. Recent advances in molecular profiling and epigenome editing, combined with the use of comparative animal and human longitudinal studies, should enable this field to transition from correlative to causal analyses.