Dietary intakes of carbohydrates in relation to prostate cancer risk: a prospective study in the Malmo Diet and Cancer cohort
Dietary intakes of carbohydrates in relation to prostate cancer risk: a prospective study in the Malmo Diet and Cancer cohort
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DOI：
10.3945/ajcn.112.039438
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发表时间：
2012-12-01
影响因子：
7.1
通讯作者：
Wirfalt, Elisabet
中科院分区：
文献类型：
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作者：
Drake, Isabel;Sonestedt, Emily;Wirfalt, Elisabet
背景资料：饮食中的碳水化合物与前列腺癌有关。目的：我们的目的是在马尔莫饮食和癌症队列中，研究饮食中碳水化合物、纤维及其食物来源的摄入量与前列腺癌风险之间的关系，包括总体和病例严重程度。设计：该分析包括8128名年龄在45-73岁之间的男性，他们没有癌症、心血管疾病或糖尿病史，被归类为能量充足的报告者。在平均随访15年后，817名男性被诊断为前列腺癌。我们使用考克斯比例风险回归模型之间的关联能量调整的营养和食物摄入量与前列腺癌的风险事件，与竞争的非前列腺癌的死亡风险causestaken consider.Results：调整后的年龄和其他已知的或潜在的危险因素，我们没有观察到总碳水化合物或膳食纤维和前列腺癌之间的关联。我们观察到低纤维谷物的摄入量与总体和低风险前列腺癌之间的正相关性，以及蛋糕和饼干以及米饭和面食的摄入量与低风险前列腺癌之间的正相关性（所有P趋势< 0.05）。与零含糖饮料消费相比，高含糖饮料摄入量与症状性前列腺癌风险增加相关（HR：1.38; 95% CI：1.04）。1.84）.结论：这项具有高有效性饮食数据的大型研究的结果表明，大量摄入精制碳水化合物可能与前列腺癌风险增加有关。然而，我们没有观察到与高风险前列腺癌的显着关联，并不是所有通常富含精制碳水化合物的食物都与前列腺癌有关。Ant J Clin Nutr 2012;96：1409-18.
Background: Dietary carbohydrates have been implicated in relation to prostate cancer.Objective: Our objective was to examine the associations between dietary intakes of carbohydrates, fiber, and their food sources and risk of prostate cancer, overall and by case severity, in the Malmo Diet and Cancer cohort.Design: The analysis included 8128 men aged 45-73 y without a history of cancer, cardiovascular disease, or diabetes and who were classified as adequate energy reporters. After a median follow-up time of 15 y, prostate cancer was diagnosed in 817 men. We used Cox proportional hazards regression to model associations between energy-adjusted nutrient and food intakes with risk of incident prostate cancer, with competing risk of death from non prostate cancer causes taken into account.Results: After adjustment for age and other known or potential risk factors, we observed no associations between total carbohydrates or dietary fiber and prostate cancer. We observed positive associations between the intake of low-fiber cereals with overall and low-risk prostate cancer and between intakes of cake and biscuits and rice and pasta with low-risk prostate cancer (all P-trend < 0.05). A high intake compared with zero consumption of sugar-sweetened beverages was associated with increased risk of symptomatic prostate cancer (HR: 1.38; 95% CI: 1.04. 1.84).Conclusions: Results from this large study with high-validity dietary data suggest that a high intake of refined carbohydrates may be associated with increased risk of prostate cancer. However we observed no significant associations with high-risk prostate cancer, and not all foods that are typically high in refined carbohydrates were associated with prostate cancer. Ant J Clin Nutr 2012;96:1409-18.