Tsetse fly saliva accelerates the onset of Trypanosoma brucei infection in a mouse model associated with a reduced host inflammatory response
Tsetse fly saliva accelerates the onset of Trypanosoma brucei infection in a mouse model associated with a reduced host inflammatory response
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DOI：
10.1128/iai.01046-06
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发表时间：
2006-11-01
影响因子：
3.1
通讯作者：
Magez, Stefan
中科院分区：
文献类型：
--
作者：
Caljon, Guy;Van Den Abbeele, Jan;Magez, Stefan
采采蝇(Glossina sp.)是传播非洲锥虫、在非洲大陆引起人类昏睡病和兽医感染的原生动物寄生虫的媒介。这些以血为食的双翅目昆虫在觅食部位沉积唾液，这使得觅血过程成为可能。在这里，我们证明采采蝇唾液也加速了布氏锥虫感染的发生。这种效应与感染起始部位的炎症反应减少(反映为白细胞介素6[IL-6]和IL-12信使核糖核酸的减少)以及较低的杀锥虫性细胞因子肿瘤坏死因子的血清浓度有关。与锥虫清除有关的变异型表面糖蛋白特异性抗体亚型免疫球蛋白M(IgM)和IgG2a不受抑制。我们认为采采蝇唾液通过抑制参与寄生虫控制的局部和全身炎症反应来加速锥虫感染的发生。
Tsetse flies (Glossina sp.) are the vectors that transmit African trypanosomes, protozoan parasites that cause human sleeping sickness and veterinary infections in the African continent. These blood-feeding dipteran insects deposit saliva at the feeding site that enables the blood-feeding process. Here we demonstrate that tsetse fly saliva also accelerates the onset of a Trypanosoma brucei infection. This effect was associated with a reduced inflammatory reaction at the site of infection initiation (reflected by a decrease of interleukin-6 [IL-6] and IL-12 mRNA) as well as lower serum concentrations of the trypanocidal cytokine tumor necrosis factor. Variant-specific surface glycoprotein-specific antibody isotypes immunoglobulin M (IgM) and IgG2a, implicated in trypanosome clearance, were not suppressed. We propose that tsetse fly saliva accelerates the onset of trypanosome infection by inhibiting local and systemic inflammatory responses involved in parasite control.