Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: Novel prognostic factors of nasopharyngeal carcinoma
Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: Novel prognostic factors of nasopharyngeal carcinoma
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DOI：
10.1016/j.canlet.2012.12.002
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发表时间：
2013-04-30
期刊：
影响因子：
9.7
通讯作者：
Yoshizaki, Tomokazu
中科院分区：
文献类型：
--
作者：
Kitagawa, Noriko;Kondo, Satoru;Yoshizaki, Tomokazu
鼻咽癌 (NPC) 是一种与 EB 病毒相关的癌症。我们通过免疫组织化学染色分析了 74 例鼻咽癌活检标本中 Siah1 的表达以及 LMP1 和 HIF1 α 的表达，发现 Siah1 的表达与晚期肿瘤状态和分期显着相关。此外，Siah1 阳性和 HIF1 α 阳性病例的预后明显较差。 LMP1 的表达评分与 Siah1 的表达评分显着相关，而 LMP1 表达与评估的其他标记之间几乎没有相关性。这是第一项评估鼻咽癌中Siah1和HIF1α表达模式和临床意义的研究，这种评估对于识别那些预后不良的高风险患者很有价值。 (C) 2012 Elsevier Ireland Ltd. 保留所有权利。
Nasopharyngeal carcinoma (NPC) is an EBV-associated cancer. We analysed Siah1 expression as well as LMP1 and HIF1 alpha expression by immuno-histochemical staining in 74 NPC biopsy specimens and found that the expression of Siah1 was significantly correlated with advanced tumour status and stage. Moreover, Siah1-positive and HIF1 alpha-positive cases had significantly worse prognoses. The expression score for LMP1 was remarkably correlated with that of Siah1, whereas there was little correlation between LMP1 expression and the other markers evaluated. This is the first study to evaluate the pattern and clinical significance of Siah1 and HIF1 alpha expression in NPC, and such an evaluation is valuable for identifying those patients at a high risk for a poor prognosis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.