Chlorthalidone attenuates the reduction in total cholesterol and small, dense LDL cholesterol subclass associated with weight loss.
Chlorthalidone attenuates the reduction in total cholesterol and small, dense LDL cholesterol subclass associated with weight loss.
复制标题
氯噻酮可减弱与减肥相关的总胆固醇和小而密的低密度脂蛋白胆固醇亚类的减少。
DOI：
10.1093/ajh/6.7.636
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发表时间：
1993
影响因子：
3.2
通讯作者：
GrimmJr,R
中科院分区：
文献类型：
--
作者：
Bradley,K;Flack,JM;Belcher,J;Elmer,P;Miller,P;GrimmJr,R
已知噻嗪类利尿剂可升高总胆固醇和LDL胆固醇。为了评估氯噻酮是否影响致动脉粥样硬化的小密度LDL 3（LDL 3）水平，我们在34名年龄在35至57岁的轻度高血压（DBP 90至104 mm Hg）非吸烟男性中进行了为期12周的双盲随机安慰剂对照临床试验。我们的先验假设，氯噻酮提高低密度脂蛋白3水平没有得到证实。然而，与体重减轻相关的LDL 3（P = .03）和总胆固醇（P = .08）的下降被氯噻酮减弱。由于在伴有高胆固醇血症的高血压患者的临床管理过程中通常规定减肥，因此在这些患者的管理中应考虑氯噻酮对胆固醇降低的减弱作用。美国高血压杂志1993;6：636- 639
Thiazide diuretics are known to raise total and LDL cholesterol. To assess whether chlorthalidone affected levels of putatively atherogenic small, dense LDL (LDL 3), we conducted a 12 week double blind randomized, placebo controlled clinical trial in 34 nonsmoking men aged 35 to 57 years with mild hypertension (DBP 90 to 104 mm Hg). Our a priori hypothesis that chlorthalidone raised LDL 3 levels was not confirmed. However, the fall in LDL 3 (P = .03) and total cholesterol (P = .08) associated with weight loss was attenuated by chlorthalidone. Since weight loss is commonly prescribed during the clinical management of hypertensives with concomitant hypercholesterolemia, consideration should be given to the attenuating effect of chlorthalidone on cholesterol reduction in the management of these patients. Am J Hypertens 1993;6:636- 639