Do schools moderate the genetic determinants of smoking?
Do schools moderate the genetic determinants of smoking?
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DOI：
10.1007/s10519-008-9197-0
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发表时间：
2008-05-01
影响因子：
2.6
通讯作者：
Hewitt, John K.
中科院分区：
文献类型：
--
作者：
Boardman, Jason D.;Saint Onge, Jarron M.;Hewitt, John K.
本文使用国家青少年健康纵向研究的数据来研究学校层面的社会和制度因素在多大程度上缓和了吸烟的遗传倾向。我们的分析依赖于84所学校内1,198对兄弟姐妹和双胞胎的子样本。我们开发了一个多层次的建模扩展基于回归的定量遗传技术来计算学校特定的遗传力估计。我们发现，吸烟开始（h（2）= 0.51）和每日吸烟（h（2）= 0.58）都受到遗传影响。而吸烟发作的遗传影响是一致的学校，我们表明，学校温和的遗传性日常吸烟。在最受欢迎的学生也是吸烟者的学校中，每日吸烟的遗传率最高，而在大多数学生是非西班牙裔和白色的学校中，每日吸烟的遗传率降低。这些发现对基因-环境相互作用的文献做出了重要贡献。
This paper uses data from the National Longitudinal Study of Adolescent Health to examine the extent to which school-level social and institutional factors moderate genetic tendencies to smoke cigarettes. Our analysis relies on a sub-sample of 1,198 sibling and twin pairs nested within 84 schools. We develop a multilevel modeling extension of regression-based quantitative genetic techniques to calculate school-specific heritability estimates. We show that smoking onset (h(2) = .51) and daily smoking (h(2) = .58) are both genetically influenced. Whereas the genetic influence on smoking onset is consistent across schools, we show that schools moderate the heritability of daily smoking. The heritability of daily smoking is the highest within schools in which the most popular students are also smokers and reduced within schools in which the majority of the students are non-Hispanic and white. These findings make important contributions to the literature on gene-environment interactions.