1H MR spectroscopy with external reference solution at 1.5 T for differentiating malignant and benign breast lesions: comparison using qualitative and quantitative approaches
1H MR spectroscopy with external reference solution at 1.5 T for differentiating malignant and benign breast lesions: comparison using qualitative and quantitative approaches
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DOI：
10.1007/s00330-012-2555-6
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发表时间：
2013-01-01
影响因子：
5.9
通讯作者：
Kimura, Fumiko
中科院分区：
文献类型：
--
作者：
Mizukoshi, Waka;Kozawa, Eito;Kimura, Fumiko
为了在定性和定量方法的基础上比较质子（H-1）磁共振波谱（MRS）在区分良性和恶性乳腺病变方面的诊断能力。我们对 208 个乳腺病变进行了单体素 H-1 MRS，确定了一个清晰的总复合胆碱化合物（tCho）峰，其信噪比为千分之一2，代表恶性肿瘤（定性方法），并将 tCho 浓度等于或大于临界值视为代表恶性肿瘤（定量方法）。我们使用 Akaike 信息标准 (AIC) 和 McFadden's R (2) 比较了两种方法的诊断能力。组织学上，169 个病变为恶性；169 个病变为恶性。 39 were benign.定性方法显示区分恶性和良性病变的敏感性为 84.6%，特异性为 51.3%。恶性肿瘤的平均 tCho 浓度为 1.13 mmol/kg，良性肿瘤的平均 tCho 浓度为 0.43 mmol/kg。最佳截止点为 0.61 mmol/kg，使用该值可实现 68.1% 的敏感性和 79.4% 的特异性。计算出的 AIC 和 R (2) 评分表明定量方法在区分恶性肿瘤方面具有优越性。定量 MRS 在区分恶性与良性病变方面比定性 MRS 具有更高的特异性，并且作为常规乳腺 MR 成像中的附加检查可能更有用。aEuro cent 乳房磁共振波谱有助于区分恶性与良性病变。aEuro cent 磁共振波谱甚至显示良性病变中的胆碱信号。aEuro cent 乳腺癌中的胆碱浓度高于乳腺癌中的胆碱浓度。定量磁共振波谱比定性磁共振波谱更好地区分乳腺恶性肿瘤。
To compare the diagnostic capability of proton (H-1) magnetic resonance spectroscopy (MRS) in differentiating benign from malignant breast lesions on the basis of qualitative and quantitative approaches.We performed single-voxel H-1 MRS for 208 breast lesions, identified a clear total composite choline compounds (tCho) peak of signal-to-noise of a parts per thousand yen2 to represent malignancy (qualitative approach), and regarded tCho concentration equal to or greater than the cut-off value to represent malignancy (quantitative approach). We compared the diagnostic ability of both approaches using the Akaike information criterion (AIC) and McFadden's R (2).Histologically, 169 lesions were malignant; 39 were benign. The qualitative approach demonstrated 84.6 % sensitivity and 51.3 % specificity for differentiating malignant and benign lesions. The mean tCho concentration was 1.13 mmol/kg for malignancy, 0.43 mmol/kg for benignity. The optimal cut-off point was 0.61 mmol/kg, use of which achieved 68.1 % sensitivity and 79.4 % specificity. Calculated AIC and R (2) score suggested the superiority of the quantitative approach for differentiating malignancy.Quantitative MRS provides higher specificity than qualitative MRS for differentiating malignant from benign lesions and could be more useful as an additional examination in routine breast MR imaging.aEuro cent Magnetic resonance spectroscopy of the breast helps distinguish malignant from benign lesions.aEuro cent Magnetic resonance spectra demonstrate a choline signal even from benign lesions.aEuro cent Choline concentration is higher in breast carcinomas than in benign lesions.aEuro cent Quantitative magnetic resonance spectroscopy differentiates breast malignancies better than qualitative MRS.