Vitamin B12 and folate deficiency in later life
Vitamin B12 and folate deficiency in later life
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DOI：
10.1093/ageing/afg109
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发表时间：
2004-01-01
期刊：
影响因子：
6.7
通讯作者：
Scott, JM
中科院分区：
文献类型：
--
作者：
Clarke, R;Evans, JG;Scott, JM
目的：研究维生素B12缺乏症和叶酸缺乏症的患病率在以后的生活中的老年人口的代表性样本在UnitedKingdom.Design：一个基于人口的横断面分析3,511人年龄在65岁或以上的三项研究被用来估计年龄特异性患病率的维生素B12缺乏症和叶酸缺乏症。如果血清维生素B12 < 150 pmol/l（“低维生素B12”），则通常诊断为维生素B12缺乏症。我们将“代谢显著性维生素B12缺乏症”定义为维生素B12 < 200 pmol/l和血液总同型半胱氨酸>20 mumol/l。叶酸缺乏症，通常指血清叶酸
Objectives: to examine the prevalence of vitamin B12 deficiency and folate deficiency in later life in representative samples of the elderly population in the United Kingdom.Design: a population-based cross-sectional analysis of 3,511 people aged 65 years or older from three studies was used to estimate the age-specific prevalence of vitamin B12 deficiency and of folate deficiency. Vitamin B12 deficiency is conventionally diagnosed if serum vitamin B12 < 150 pmol/l ('low vitamin B12'). We defined 'metabolically significant vitamin B12 deficiency' as vitamin B12 < 200 pmol/l and blood total homocysteine >20 mumol/l. Folate deficiency, which usually refers to serum folate