A hybrid bioorganic interface for neuronal photoactivation
A hybrid bioorganic interface for neuronal photoactivation
复制标题
DOI：
10.1038/ncomms1164
复制
发表时间：
2011-01-01
影响因子：
16.6
通讯作者：
Lanzani, Guglielmo
中科院分区：
文献类型：
--
作者：
Ghezzi, Diego;Antognazza, Maria Rosa;Lanzani, Guglielmo
实现视网膜假体装置的一个关键问题是将光携带的信息可靠地转换成视觉信息处理网络中特定的电活动模式。软有机材料可用于将人工传感器与神经组织耦合。在这里，我们将初级神经元网络与有机混合物连接起来。我们表明，原代神经元可以成功生长到聚合物层上，而不影响活性材料的光电特性或神经元网络的生物功能。此外，可以用可见光短脉冲以时间可靠和空间选择性的方式触发动作电位。我们的结果可能会带来新的神经元通信和照片操纵技术，从而为人造视网膜和其他基于有机光电探测器的神经假体接口的发展铺平道路。
A key issue in the realization of retinal prosthetic devices is reliable transduction of information carried by light into specific patterns of electrical activity in visual information processing networks. Soft organic materials can be used to couple artificial sensors with neuronal tissues. Here, we interface a network of primary neurons with an organic blend. We show that primary neurons can be successfully grown onto the polymer layer without affecting the optoelectronic properties of the active material or the biological functionality of neuronal network. Moreover, action potentials can be triggered in a temporally reliable and spatially selective manner with short pulses of visible light. Our results may lead to new neuronal communication and photo manipulation techniques, thus paving way to the development of artificial retinas and other neuroprosthetic interfaces based on organic photodetectors.