Elevated expression of UBE2T exhibits oncogenic properties in human prostate cancer.
Elevated expression of UBE2T exhibits oncogenic properties in human prostate cancer.
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UBE2T 表达升高在人类前列腺癌中表现出致癌特性
DOI：
10.18632/oncotarget.4712
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发表时间：
2015-09-22
期刊：
影响因子：
--
通讯作者：
Wei G
中科院分区：
文献类型：
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作者：
Wen M;Kwon Y;Wang Y;Mao JH;Wei G
泛素结合酶E2T（UBE2T）在人前列腺癌中的表达增加。然而，UBE2T是否在前列腺癌的发展中发挥任何功能性作用仍然未知。我们在这里报告的第一个功能特性的UBE2T在前列腺癌的发生。前列腺癌组织阵列分析证实了UBE2T在前列腺癌中的上调，特别是那些具有远处转移的前列腺癌。此外，UBE2T表达水平越高，前列腺癌患者的预后越差。UBE2T的异位表达显著促进前列腺癌细胞的增殖、运动和侵袭，而UBE2T通过shRNA的耗竭显著抑制前列腺癌细胞的这些能力。异种移植小鼠模型研究表明，UBE2T的过表达促进而UBE2T的缺失显著抑制肿瘤的形成和转移。总的来说，我们确定了UBE2T在前列腺癌发展和进展中的关键作用。这些发现可以作为未来研究的框架，旨在更全面地确定UBE2T作为潜在的治疗靶点。
Increased expression of ubiquitin-conjugating enzyme E2T (UBE2T) is reported in human prostate cancer. However, whether UBE2T plays any functional role in prostate cancer development remains unknown. We here report the first functional characterization of UBE2T in prostate carcinogenesis. Prostate cancer tissue array analysis confirmed upregulation of UBE2T in prostate cancer, especially these with distant metastasis. Moreover, higher level of UBE2T expression is associated with poorer prognosis of prostate cancer patients. Ectopic expression of UBE2T significantly promotes prostate cancer cell proliferation, motility and invasion, while UBE2T depletion by shRNA significantly inhibits these abilities of prostate cancer cells. Xenograft mouse model studies showed that overexpression of UBE2T promotes whereas UBE2T depletion inhibits tumor formation and metastasis significantly. Collectively, we identify critical roles of UBE2T in prostate cancer development and progression. These findings may serve as a framework for future investigations designed to more comprehensive determination of UBE2T as a potential therapeutic target.