QUANTITATIVE DESCRIPTION OF SODIUM AND POTASSIUM CURRENTS AND COMPUTED ACTION POTENTIALS IN MYXICOLA GIANT AXONS
QUANTITATIVE DESCRIPTION OF SODIUM AND POTASSIUM CURRENTS AND COMPUTED ACTION POTENTIALS IN MYXICOLA GIANT AXONS
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DOI：
10.1085/jgp.61.3.361
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发表时间：
1973-01-01
影响因子：
3.8
通讯作者：
SCHAUF, CL
中科院分区：
文献类型：
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作者：
GOLDMAN, L;SCHAUF, CL
的钠和钾电导的Myxicola巨大的轴突进行了分析，在霍奇金-赫胥黎m，n和h变量。钾的电导率与n2成正比。在存在条件性超极化时，延迟电流沿时间轴向右沿着。当这种效应接近饱和时，钾电导率与氮成正比。假设钠电导与马赫数成正比。有一个范围的电位，其中rh和h值拟合的钠电导的衰减可以比较那些从调节脉冲的影响确定。两种方法测定的Th值不一致。通过两种方法测定的h值的比较表明，钠电流的失活不受Hodgkin-Huxley h变量的影响。计算机模拟表明，动作电位，阈值和阈下行为可以占不参考数据的初始条件的影响。然而，恢复现象（耐火性，重复放电）只能通过参考这些数据来解释。得出的结论是，钠电导不受两个独立的一阶变量的产品。
An analysis of the sodium and potassium conductances of Myxicola giant axons was made in terms of the Hodgkin-Huxley m, n, and h variables. The potassium conductance is proportional to n2. In the presence of conditioning hyperpolarization, the delayed current translates to the right along the time axis. When this effect was about saturated, the potassium conductance was proportional to n. The sodium conductance was described by assuming it proportional to mah. There is a range of potentials for which rh and h values fitted to the decay of the sodium conductance may be compared to those determined from the effects of conditioning pulses. Th values determined by the two methods do not agree. A comparison of h, values determined by the two methods indicated that the inactivation of the sodium current is not governed by the Hodgkin-Huxley h variable. Computer simulations show that action potentials, threshold, and subthreshold behavior could be accounted for without reference to data on the effects of initial conditions. However, recovery phenomena (refractoriness, repetitive discharges) could be accounted for only by reference to such data. It was concluded that the sodium conductance is not governed by the product of two independent first order variables.