Ablation of Promyelocytic Leukemia Protein (PML) Re-patterns Energy Balance and Protects Mice from Obesity Induced by a Western Diet
Ablation of Promyelocytic Leukemia Protein (PML) Re-patterns Energy Balance and Protects Mice from Obesity Induced by a Western Diet
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DOI：
10.1074/jbc.m113.487595
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发表时间：
2013-10-11
影响因子：
4.8
通讯作者：
Kao, Hung-Ying
中科院分区：
文献类型：
--
作者：
Cheng, Xiwen;Guo, Shuang;Kao, Hung-Ying
早幼粒细胞白血病蛋白是众所周知的肿瘤抑制因子，但其在代谢中的作用在很大程度上是未知的。PML基因缺失的小鼠（KO小鼠）在肝脏、脂肪组织和骨骼肌中表现出基因表达改变，脂肪酸代谢速率加快，葡萄糖代谢异常，组成性AMP激活激酶（AMPK）激活和骨骼肌胰岛素抵抗。最后，增加的能量消耗速率保护PML KO小鼠免受西方饮食诱导的肥胖的影响。总的来说，我们的研究揭示了PML在调节小鼠代谢和能量平衡方面的一个以前未被认识到的作用。
The promyelocytic leukemia protein is a well known tumor suppressor, but its role in metabolism is largely unknown. Mice with a deletion in the gene for PML (KO mice) exhibit altered gene expression in liver, adipose tissue, and skeletal muscle, an accelerated rate of fatty acid metabolism, abnormal glucose metabolism, constitutive AMP-activating kinase (AMPK) activation, and insulin resistance in skeletal muscle. Last, an increased rate of energy expenditure protects PML KO mice from the effects of obesity induced by a Western diet. Collectively, our study uncovers a previously unappreciated role of PML in the regulation of metabolism and energy balance in mice.