On resetting of "barostats" in hypertensive patients.
On resetting of "barostats" in hypertensive patients.
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关于高血压患者“气压调节器”的重置。
DOI：
10.1001/jama.1967.03130050035010
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发表时间：
1967
期刊：
影响因子：
--
通讯作者：
W. M. Smith
中科院分区：
文献类型：
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作者：
R. Thurm;W. M. Smith
大约10年前，研究表明，当通过Goldblatt夹在狗中诱导高血压时，颈动脉窦复位，变得对升高的压力不敏感。那么，抗高血压治疗是否可能导致这种“恒压器”设置的降低，从而允许停止治疗？美国公共卫生服务合作高血压研究提供了一个评估这个问题的机会。69名对各种抗高血压药物有反应的人在平均反应期超过两年后停止了药物治疗，并在家中不间断地记录了血压。25例患者保持应答（平均舒张压低于90 mm Hg）至少5个月。在这组患者中，9例患者在5至24个月后由于舒张压逐渐升高而需要重新开始治疗。
Approximately ten years ago, it was shown that when hypertension was induced in dogs by a Goldblatt clamp, the carotid sinus was reset, becoming insensitive to the elevated pressure. Is it then conceivable that antihypertensive therapy may result in a lowering of this "barostat" setting, permitting discontinuation of therapy? The US Public Health Service Cooperative Study of Hypertension provided an opportunity to evaluate this question. Sixty-nine "responders" to various antihypertensive agents had their medications discontinued after an average response period of more than two years, with uninterrupted recordings of the pressure at home. Twenty-five patients remained responders (average diastolic pressure below 90 mm Hg) for at least five months. Of this group, nine required reinstitution of therapy, 5 to 24 months later, due to the gradual rise of their diastolic pressures.