Ion channels and membrane rafts in apoptosis
Ion channels and membrane rafts in apoptosis
复制标题
细胞凋亡中的离子通道和膜筏
DOI：
10.1007/s00424-004-1259-4
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
E. Gulbins
中科院分区：
文献类型：
--
作者：
I. Szabó;C. Adams;E. Gulbins
离子通道已被证明是诱导和执行细胞凋亡的核心因素。特别是，线粒体离子通道，不仅包括通透性过渡孔，还包括线粒体atp敏感（mKATP）通道以及线粒体钙活化钾通道，在线粒体凋亡变化中起关键作用。细胞膜上被诱导凋亡改变的离子通道包括钾离子、氯离子和钙离子通道。Kv1.3钾通道是参与细胞凋亡的最具特征的离子通道，缺乏Kv1.3的细胞的遗传模型表明，Kv1.3至少在某些形式的细胞凋亡中起关键作用。然而，细胞凋亡过程中调控离子通道的机制仍不明确。最近的研究表明，细胞膜中不同的膜结构域（称为筏）在细胞凋亡过程中调节离子通道。小的鞘脂和胆固醇富集膜结构域被许多凋亡刺激修饰，形成大的神经酰胺富集膜平台。这些平台用于聚集受体分子，重组细胞内信号分子，包括离子通道，使离子通道与其调节因子密切接触和/或从特定离子通道中分离蛋白质。最后，细胞膜的脂质组成可能直接参与离子通道的调节。
Ion channels have been demonstrated to be a central element in the induction and the execution of apoptosis. In particular, mitochondrial ion channels, including not only the permeability transition pore but also a mitochondrial, ATP-sensitive (mKATP) channel as well as a mitochondrial calcium-activated potassium channel are involved critically in apoptotic changes in mitochondria. Ion channels in the cell membrane that are altered by induction of apoptosis include potassium, chloride and calcium channels. The Kv1.3 potassium channel belongs to the best-characterized ion channels involved in apoptosis and a genetic model of cells deficient for Kv1.3 has indicated a critical role for Kv1.3, at least in some forms of apoptosis. The mechanisms regulating ion channels during apoptosis are, however, still poorly defined. Recent studies have suggested a function for distinct membrane domains, termed rafts, in the cell membrane for the regulation of ion channels during apoptosis. Small sphingolipid- and cholesterol-enriched membrane domains are modified by many apoptotic stimuli to form large ceramide-enriched membrane platforms. These platforms serve to cluster receptor molecules, to re-organize intracellular signalling molecules including ion channels, to bring ion channels into close contact with their regulators and/or to separate proteins from a specific ion channel. Finally, the lipid composition of the cell membrane might be involved directly in ion channel regulation.
DOI：
10.1074/jbc.271.34.20465
发表时间：
1996-08
期刊：
The Journal of Biological Chemistry
影响因子：
--
作者：
I. Szabó;E. Gulbins;H. Apfel;Xinfeng Zhang;P. Barth;A. Busch;K. Schlottmann;O. Pongs;F. Lang
通讯作者：
I. Szabó;E. Gulbins;H. Apfel;Xinfeng Zhang;P. Barth;A. Busch;K. Schlottmann;O. Pongs;F. Lang
DOI：
10.1073/pnas.140216197
发表时间：
2000-08-15
影响因子：
11.1
作者：
Maeno, E;Ishizaki, Y;Okada, Y
通讯作者：
Okada, Y