ANAPHYLAXIS IN MAST CELL-DEFICIENT MICE
ANAPHYLAXIS IN MAST CELL-DEFICIENT MICE
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DOI：
10.1111/1523-1747.ep12340431
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发表时间：
1984-01-01
影响因子：
6.5
通讯作者：
PINCUS, SH
中科院分区：
文献类型：
--
作者：
JACOBY, W;CAMMARATA, PV;PINCUS, SH
通过检测全身过敏反应的发生，寻找肥大细胞缺陷小鼠功能缺陷的证据。W/Wv肥大细胞缺陷型小鼠和野生型对照动物通过注射牛血清白蛋白致敏，随后进行激发。9/10只W/Wv肥大细胞缺陷小鼠和10/10只对照小鼠表现出过敏反应体征，包括死亡。尽管对照组动物的组胺水平较高，但在抗原激发前后未观察到差异。外周血嗜碱性粒细胞的数量在W/Wv和野生型小鼠中相同。在使用这些动物研究疾病时必须谨慎。
Evidence of a functional deficit in mast cell-deficient mice was sought by testing for the development of systemic anaphylaxis. W/Wv mast cell-deficient mice and wild type control animals were sensitized by injection of bovine serum albumin, and were subsequently challenged. Nine of 10 W/Wv mast cell-deficient mice and 10/10 control mice demonstrated signs of anaphylaxis, including death. Although histamine levels were higher in control animals, no differences were noted before and after antigen challenge. The numbers of peripheral blood basophils were the same in W/Wv and wild type mice. Caution is necessary in the use of these animals to study disease.