In vivo droplet vaporization for occlusion therapy and phase aberration correction
In vivo droplet vaporization for occlusion therapy and phase aberration correction
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DOI：
10.1109/tuffc.2002.1009331
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发表时间：
2002-06-01
影响因子：
3.6
通讯作者：
Carson, PL
中科院分区：
文献类型：
--
作者：
Kripfgans, OD;Fowlkes, JB;Carson, PL
目的是确定经皮微滴乳剂（90%，30 μ m）是否暂时在体内。当以大量密度使用时，这种气泡可能堵塞目标毛细血管床。或者，对于非常稀疏的液滴群体，所产生的气泡可以用作超声成像中相位畸变校正的点信标。气泡可以通过注射的过热十二碳戊烷液滴的声学液滴蒸发（ADV）在体内产生。液滴在声场中蒸发，其峰值稀疏压力超过明确定义的阈值[1]，[2]。在这项新工作中，已经发现动脉内和静脉内注射可以用于将乳剂引入血流中，用于随后的原位ADV（临床扫描仪上的Band M模式）。静脉内给药导致较低的气泡产量，可能是因为肺中的过滤。血液体积的稀释或其他循环效应。结果表明，对于闭塞目的，可以实现34%的局部血流量减少。通过静脉注射和ADV创建相对于白色物质具有+24 dB反向散射振幅的单个点信标。
The objective was to determine whether a transpulmonary droplet emulsion (90%, 30 mum) temporarily in vivo. Such bubbles could occlude a targeted capillary bed when used in a large number density. Alternatively, for a very sparse population of droplets, the resulting gas bubbles could serve as point beacons for phase aberration corrections in ultrasonic imaging. Gas bubbles can be made in vivo by acoustic droplet vaporization (ADV) of injected, superheated, dodecafluoropentane droplets. Droplets vaporize in an acoustic field whose peak rarefactional pressure exceeds a well-defined threshold [1], [2]. In this new work, it has been found that intraarterial and intravenous injections can be used to introduce the emulsion into the blood stream for subsequent ADV (Band M-mode on a clinical scanner) in situ. Intravenous administration results in a lower gas bubble yield, possibly because of filtering in the lung. dilution in the blood volume, or other circulatory effects. Results show that for occlusion purposes, a reduction in regional blood flow of 34% can be achieved. Individual point beacons with a +24 dB backscatter amplitude relative to white matter were created by intravenous injection and ADV.