Vascular flow density in pathological myopia: an optical coherence tomography angiography study.
Vascular flow density in pathological myopia: an optical coherence tomography angiography study.
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DOI：
10.1136/bmjopen-2016-013571
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发表时间：
2017-02-03
期刊：
影响因子：
2.9
通讯作者：
Wei W
中科院分区：
文献类型：
--
作者：
Mo J;Duan A;Chan S;Wang X;Wei W
目的应用光学相干断层扫描（OCT）血管成像技术研究病理性近视眼的血管密度。2015年12月至2016年3月进行了一项前瞻性比较研究。受试者在北京同仁医院招募。共入组131只眼，分为3组：正视眼（EM;平均等效球镜（MSE）0.50 D ~ − 0.50 D）45只眼，高度近视眼（HM; MSE ≤− 6.00 D，无病理改变）41只眼，病理性近视眼（PM; MSE ≤− 6.00 D且眼轴长（AL）≥26.5 mm，有病理改变）45只眼。 测量黄斑区、脉络膜毛细血管区和径向乳头周围毛细血管（RPC）的血流密度，并进行组间比较，分析其与AL和最佳矫正视力（BCVA）的关系。三组间黄斑区、脉络膜毛细血管区及RPC血流密度差异有显著性意义（p<0.05）。多重比较显示，与EM和HM组相比，PM组的黄斑和RPC血流密度显著降低（p<0.05），但PM和HM组之间的脉络膜毛细血管血流密度无显著差异（p=0.731）。与EM组相比，HM组黄斑区和弓状纤维区的视网膜血流密度没有降低。此外，AL与黄斑表面血流密度呈负相关（β=−0.542，p<0.001），黄斑深血流密度（β=−0.282，p=0.002）和RPC流密度（β=-0.522，p<0.001）;最佳矫正视力与黄斑表面血流密度呈正相关深黄斑血流密度（β =0.373，p<0.001）和脉络膜毛细血管血流密度（β=0.291，p=0.001）。病理性近视组黄斑和RPC血流密度较高度近视组和正视组降低。与正视眼相比，高度近视眼黄斑区和弓状纤维区视网膜血流密度无明显降低。此外，黄斑和RPC血流密度与AL呈负相关，黄斑血流密度与BCVA呈正相关。
To investigate vascular flow density in pathological myopia with optical coherence tomography (OCT) angiography. A prospective comparative study was conducted from December 2015 to March 2016. Participants were recruited in Beijing Tongren Hospital. A total of 131 eyes were enrolled, which were divided into three groups: 45 eyes with emmetropia (EM; mean spherical equivalent (MSE) 0.50D to −0.50D), 41 eyes with high myopia (HM; MSE ≤−6.00D, without pathological changes), and 45 eyes with pathological myopia (PM; MSE ≤−6.00D and axial length (AL) ≥26.5 mm, and with pathological changes). Macular, choriocapillaris and radial peripapillary capillary (RPC) flow densities were measured and compared between groups, and their relationships with AL and best corrected visual acuity (BCVA) were analysed. Significant differences were found in macular, choriocapillaris and RPC flow densities among the three groups (p<0.05). Multiple comparisons revealed that, compared with the EM and HM groups, macular and RPC flow densities of the PM group were significantly decreased (p<0.05), but no significant difference in choriocapillaris flow density was found between the PM and HM groups (p=0.731). Compared with the EM group, retinal flow density in the macular and arcuate fibre region was not decreased in the HM group. In addition, there was a negative correlation between AL and superficial macular flow density (β=−0.542, p<0.001), deep macular flow density (β=−0.282, p=0.002) and RPC flow density (β=−0.522, p<0.001); and a positive correlation between BCVA and superficial macular flow density (β=0.194, p=0.021), deep macular flow density (β=0.373, p<0.001), and choriocapillaris flow density (β=0.291, p=0.001). Macular and RPC flow densities decreased in pathological myopia compared with high myopia and emmetropia. No significant decrease of retinal flow density in the macular and arcuate fibre region was found in high myopic eyes compared with emmetropic eyes. Moreover, macular and RPC flow densities were negatively related to AL, and macular flow density was positively related to BCVA.