ACETYLATION OF PUROMYCIN BY STREPTOMYCES-ALBONIGER - THE PRODUCING ORGANISM
ACETYLATION OF PUROMYCIN BY STREPTOMYCES-ALBONIGER - THE PRODUCING ORGANISM
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DOI：
10.1016/0006-291x(83)91066-5
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发表时间：
1983-01-01
影响因子：
3.1
通讯作者：
JIMENEZ, A
中科院分区：
文献类型：
--
作者：
PEREZGONZALEZ, JA;VARA, J;JIMENEZ, A
S.alboniger产生了抗生素嘌呤霉素，并表达了利用乙酰辅酶A对药物进行乙酰化的酶活性。在枯草芽孢杆菌中形成的N-乙酰嘌呤霉素对蛋白质合成没有生物活性(体内测定)。
S. alboniger produced the antibiotic puromycin and expressed an enzymic activity which acetylated the drug using acetyl CoA. The N-acetyl-puromycin formed was biologically inactive against protein synthesis in Bacillus subtilis (as assayed in vivo).