Chronotype, social jet lag, sleep debt and food timing in inflammatory bowel disease
Chronotype, social jet lag, sleep debt and food timing in inflammatory bowel disease
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DOI：
10.1016/j.sleep.2018.08.002
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发表时间：
2018-12-01
期刊：
影响因子：
4.8
通讯作者：
Swanson, Garth R.
中科院分区：
文献类型：
--
作者：
Chakradeo, Prachi S.;Keshavarzian, Ali;Swanson, Garth R.
睡眠/清醒周期的偏好可以分为类别或时型。炎症性肠病(IBD)与睡眠质量差有关，而睡眠质量与疾病的严重程度有关。社交时差(SJL)是工作和空闲两天睡眠时间的差异，是昼夜节律失调的标志，而昼夜节律失调与炎症增加有关。我们调查了时型、SJL、睡眠欠债(SD)和饮食时机是否与IBD特有的并发症和较低的生活质量相关。总体而言，191名受试者(115名IBD受试者和76名健康对照组)完成了匹兹堡睡眠质量指数(PSQI)、早晚问卷(MEQ)、慕尼黑时型问卷(MCTQ)、短炎性肠病问卷(SIBDQ)和结构化食物选择问卷(SIBDQ)。时间型越晚，SIBDQ越差(r=-0.209；P<；005)。调整年龄因素后，IBD组SJL在1.32h+/-1.03比HC组1.05h+/-0.97显著增加。SJL(>；2 h)在40%的重度/复杂性克罗恩病患者中出现(包括瘘管形成或结构重建或克罗恩相关手术病史)，而在无并发症的克罗恩病患者中只有16%(P<；0.05)。与对照组相比，IBD患者的睡眠负债增加了21.90m+/-25.37vs.11.49m+/-13.58，P<；0.05。早餐或晚餐时间不一致的IBD患者SIBDQ得分较低(4.78+/-1.28 vs.5.49+/-1.02，P<；0.05；4.95+/-0.31 vs.5.42+/-0.32，P<；0.05)。总之，较晚的时间类型和昼夜节律失调的标志(社会时差、睡眠欠债和进餐时间不一致)与IBD疾病特有的并发症和/或较低的生活质量相关。(C)2018爱思唯尔B.V.保留所有权利。
The preference of the sleep/wake cycle can be grouped into categories or chronotypes. Inflammatory bowel disease (IBD) has been linked to poor sleep quality which correlates with disease severity. Social jet lag (SJL) is the difference between sleep timing on work and free days and is a marker for circadian misalignment which has been linked to increased inflammation. We investigated whether chronotype, SJL, sleep debt (SD), and food timing were associated with an IBD specific complications and a lower quality of life. Overall, 191 subjects (115 IBD subjects and 76 healthy controls (HC)) completed the Pittsburgh Sleep Quality Index (PSQI), Morningness-Eveningness Questionnaire (MEQ), Munich ChronoType Questionnaire (MCTQ), Short Inflammatory Bowel Disease Questionnaire (SIBDQ), and a structured Food Timing Questionnaire. Later chronotype (by MEQ) was associated with a worse SIBDQ (r = -0.209; P < 0.05). SJL was increased in IBD at 1.32 h +/- 1.03 vs. 1.05 h +/- 0.97 in HC, P < 0.05, when adjusted for age. SJL (>2 h) was present in 40% of severe/complicated Crohn's patients (fistulizing or structuring Crohn's or history of Crohn's related surgery) compared to only 16% of uncomplicated Crohn's patients (P < 0.05). Sleep debt was increased in IBD subjects compared to HC at 21.90 m +/- 25.37 vs. 11.49 m +/- 13.58, P < 0.05. IBD subjects with inconsistent breakfast or dinner times had lower SIBDQ scores (4.78 +/- 1.28 vs. 5.49 +/- 1.02, P < 0.05; 4.95 +/- 0.31 vs. 5.42 +/- 0.32, P < 0.05 respectively). In summary, later chronotype, and markers of circadian misalignment (social jet lag, sleep debt, and inconsistent meal timing) were associated with IBD disease specific complications and/or lower quality of life. (c) 2018 Elsevier B.V. All rights reserved.