Preventive effects of Pycnogenol® on cardiovascular risk factors (including endothelial function) and microcirculation in subjects recovering from coronavirus disease 2019 (COVID-19)
Preventive effects of Pycnogenol® on cardiovascular risk factors (including endothelial function) and microcirculation in subjects recovering from coronavirus disease 2019 (COVID-19)
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DOI：
10.23736/s0026-4806.21.07650-3
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发表时间：
2022-04-01
期刊：
影响因子：
4.7
通讯作者：
Burki, Carolina
中科院分区：
文献类型：
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作者：
Belcaro, Gianni;Cornelli, Umberto;Burki, Carolina
背景技术背景：这项开放性补充研究的目的是评估碧萝芷（R）与对照组相比对COVID-19后综合征症状的影响，以及在改善COVID-19症状恢复者的内皮功能、微循环、炎症标志物和氧化应激方面的作用。方法：60名从COVID-19症状恢复的受试者被纳入。一组30人遵循标准的恢复管理，而30名可比的受试者除了标准管理外，还接受每日150 mg碧萝芷（R）的补充（3个剂量为50 mg）。使用SM（标准管理）和SM与补充剂组合的组均逐渐改善。与对照组患者相比，补充碧萝芷（R）的患者表现出明显更好的改善。没有观察到补充剂的副作用;耐受性最佳。随着时间的推移，在所有目标测量中都可以看到逐步演变。生理检查：内皮功能，所有受试者在入选时均较低，通过释放阻塞性超收缩袖带后微循环中的血流介导扩张（FMD）和手指反应性充血（激光多普勒测量）进行评估。碧萝芷（R）组在1个月和3个月后有显著改善（P
BACKGROUND: The aim of this open supplement study was to evaluate the effects of Pycnogenol (R) in comparison with controls on symptoms of post-COVID-19 syndrome and in improving endothelial function, microcirculation, inflammatory markers and oxidative stress over 3 months in symptomatic subjects recovering from COVID-19.METHODS: Sixty subjects recovering from symptomatic COVID-19 were included. One group of 30 followed a standard recovery management while 30 comparable subjects received a supplement of 150 mg Pycnogenol (R) daily (in 3 doses of 50 mg) in addition to standard management.RESULTS: Two groups of selected subjects were comparable at baseline. The groups progressively improved both with the SM (standard management) and with the SM in combination with the supplement. Patients, supplemented with Pycnogenol (R) showed significantly better improvement compared to the control group patients. No side effects from the supplementation were observed; tolerability was optimal. The progressive evolution over time was visible in all target measurements. Physiological tests: endothelial function, low in all subjects at inclusion was assessed by flow mediated dilation (FMD) and finger reactive hyperemia in the microcirculation (laser Doppler measurements) after the release of an occluding suprasystolic cuff. It was significantly improved in the Pycnogenol (R) group after one month and after 3 months (P