A new cytotoxic biflavonoid from the rhizome of Wikstroemia indica
A new cytotoxic biflavonoid from the rhizome of Wikstroemia indica
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来自 Wikstroemia indica 根茎的新型细胞毒性双黄酮类化合物
DOI：
10.1080/14786419.2015.1062379
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发表时间：
2016-01-01
影响因子：
2.2
通讯作者：
Fan, Qin
中科院分区：
文献类型：
--
作者：
Shao, Meng;Huang, Xiao-Jun;Fan, Qin
本文报道了从印度王香根茎中分得的一个新的查耳酮双黄酮化合物3 '-羟基瑞香素A（1）和12个已知的双黄酮化合物（2-13）。它们的结构是建立在广泛的光谱方法的基础上。评价了8个分离的化合物1-3、6、7、9、12和13对癌症衍生细胞系Hep 3B、HepG 2和CNE 2的细胞毒性活性，发现1对HepG 2和CNE 2细胞系具有中等细胞毒性，IC 50值分别为65.5 +/-11.4和53.6 +/-10.1 μ M。[图形]。
One new chalcone-flavone biflavonoid, 3'-hydroxydaphnodorin A (1), together with 12 known biflavonoids (2-13), was isolated from the rhizome of Wikstroemia indica. Their structures were established on the basis of extensive spectroscopic methods. Eight isolated compounds 1-3, 6, 7, 9, 12 and 13 were evaluated for their cytotoxic activities against cancer-derived cell lines Hep3B, HepG2 and CNE2, and 1 was found to possess moderate cytotoxicity against HepG2 and CNE2 cell lines, with IC50 values of 65.5 +/- 11.4 and 53.6 +/- 10.1 mu M, respectively.[GRAPHICS].