Fluctuation effects in bidirectional cargo transport
Fluctuation effects in bidirectional cargo transport
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DOI：
10.1140/epjst/e2014-02328-2
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发表时间：
2014-12-01
影响因子：
2.8
通讯作者：
Santen, L.
中科院分区：
文献类型：
--
作者：
Klein, S.;Appert-Rolland, C.;Santen, L.
我们讨论了生物细胞中双向货物运输的理论模型，该模型由分子马达组驱动并受到热波动的影响。该模型明确地描述了分子马达在细丝上的定向运动。发动机-货物耦合通过线性弹簧实现。通过广泛的Monte Carlo模拟，我们表明，该模型描述了实验观察到的制度的异常扩散，即subdiffusive行为在短时间内，其次是在中间时间的超扩散。模型结果表明，亚扩散区是由热涨落引起的，而超扩散区是由马达活动的相关性引起的。我们还测试了双向货物运输在拥挤地区的效率，通过测量其通过增加粘度的障碍物的能力。我们的研究结果表明，高粘度的效率显着增益。
We discuss a theoretical model for bidirectional cargo transport in biological cells, which is driven by teams of molecular motors and subject to thermal fluctuations. The model describes explicitly the directed motion of the molecular motors on the filament. The motor-cargo coupling is implemented via linear springs. By means of extensive Monte Carlo simulations we show that the model describes the experimentally observed regimes of anomalous diffusion, i.e. subdiffusive behavior at short times followed by superdiffusion at intermediate times. The model results indicate that the subdiffusive regime is induced by thermal fluctuations while the superdiffusive motion is generated by correlations of the motors' activity. We also tested the efficiency of bidirectional cargo transport in crowded areas by measuring its ability to pass barriers with increased viscosity. Our results show a remarkable gain of efficiency for high viscosities.