The hypoxic ventilatory response and ventilatory long-term facilitation are altered by time of day and repeated daily exposure to intermittent hypoxia
The hypoxic ventilatory response and ventilatory long-term facilitation are altered by time of day and repeated daily exposure to intermittent hypoxia
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DOI：
10.1152/japplphysiol.00524.2010
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发表时间：
2011-01-01
影响因子：
3.3
通讯作者：
Mateika, Jason H.
中科院分区：
文献类型：
--
作者：
Gerst, David G., III;Yokhana, Sanar S.;Mateika, Jason H.
Gerst DG 3rd，Yokhana SS，Carney LM，Lee DS，Badr MS，Qureshi T，Anthouard MN，Mateika JH.低氧刺激反应和刺激长时程易化会因一天中的时间和每天重复暴露于间歇性低氧而改变。J Appl Physiol 110：15-28，2011.首次发表于2010年8月19日; doi：10.1152/japplphysiol.00524.2010.-本研究探讨了一天中的时间和重复暴露于间歇性缺氧是否对缺氧性反应（HVR）和缺氧性长时程易化（vLTF）有影响。13名患有睡眠呼吸暂停的参与者暴露于12次4分钟的等二氧化碳缺氧，然后每天进行30分钟的恢复期，持续10天。在第1天（第一天）和第10天（最后一天），参与者在晚上（PM）完成方案;在剩余的日子里，方案在早上（AM）完成。早晨的HVR较晚上增加（上午0.83 +/- 0.08 vs.下午0.64 +/- 0.11 l.min（-1）.%血氧饱和度（2）（-1）; P
Gerst DG 3rd, Yokhana SS, Carney LM, Lee DS, Badr MS, Qureshi T, Anthouard MN, Mateika JH. The hypoxic ventilatory response and ventilatory long-term facilitation are altered by time of day and repeated daily exposure to intermittent hypoxia. J Appl Physiol 110: 15-28, 2011. First published August 19, 2010; doi:10.1152/japplphysiol.00524.2010.-This study examined whether time of day and repeated exposure to intermittent hypoxia have an impact on the hypoxic ventilatory response (HVR) and ventilatory long-term facilitation (vLTF). Thirteen participants with sleep apnea were exposed to twelve 4-min episodes of isocapnic hypoxia followed by a 30-min recovery period each day for 10 days. On days 1 (initial day) and 10 (final day) participants completed the protocol in the evening (PM); on the remaining days the protocol was completed in the morning (AM). The HVR was increased in the morning compared with evening on the initial (AM 0.83 +/- 0.08 vs. PM 0.64 +/- 0.11 l.min(-1).%SaO(2)(-1); P