Effects of vibration therapy on bone mineral density in postmenopausal women with osteoporosis
Effects of vibration therapy on bone mineral density in postmenopausal women with osteoporosis
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DOI：
10.1097/00029330-200807010-00001
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发表时间：
2008-07-05
影响因子：
6.1
通讯作者：
Sun Yun-gao
中科院分区：
文献类型：
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作者：
Ruan Xiang-yan;Jin Feng-yu;Sun Yun-gao
背景：颌骨骨坏死可能与双膦酸类药物的使用有关，预计将采用非药物方法进行治疗。本研究旨在探讨无创机械振动能否抑制绝经后骨质疏松症患者的骨密度下降，提高腰椎和股骨颈的骨密度，减轻慢性腰背痛。方法将116例绝经后骨质疏松症患者分为A组(66例)和B组(50例)。A组接受振动治疗(受试者垂直站在振动台上，振动频率30 Hz，振幅5 mm，每周5次，每次10min，共6个月)，B组为对照组，不做任何治疗。分别于治疗前、治疗3个月和6个月记录L2~4骨密度、双侧股骨颈骨密度和体重指数(BMI)。治疗结束后，比较分析各组骨密度的变化。结果116例患者中，94例完成研究，其中A组51例(61.23±8.20岁)，B组43例(63.73±5.45岁)。两组患者在年龄、BMI、绝经年限、腰椎BMD、股骨颈BMD和VAS等基线指标上无显著差异。A组51例，振动治疗3个月后腰椎骨密度增加1.3%(P=0.034)，6个月时增加4.3%(P=0.000)。B组治疗后第3个月腰椎骨密度有所下降，但差异无统计学意义(P>；0.05)。术后6个月下降1.9%(P<0.05)。6个月时骨密度增加3.2%(P
Background Jaw osteonecrosis possibly associated with the administration of bisphosphonates is expected to be treated with a non-pharmacologic approach. This study aimed to determine whether noninvasive, mechanically mediated vibration would inhibit the decline in bone mineral density (BMD) that follows menopause, enhance the BMD of the lumbar and femoral neck, and reduce chronic back pain in postmenopausal women with osteoporosis.Methods A total of 116 postmenopausal women with osteoporosis participated in this study, and they were divided into groups A (66 patients) and B (50). Group A received vibration treatment (Subjects vertically stand on the vibration platform, with a vibration frequency of 30 Hz, amplitude of 5 mm; they received the treatment five times per week, ten minutes each time and totally for six months), whereas women of group B served as controls without any treatment. L2-4 BMD, bilateral femoral neck BMD, and body mass index (BMI) were recorded before the treatment or at the third and sixth months of the treatment respectively. After the ending of the treatment, the change of BMD in each group was compared and analyzed. Chronic back pain was evaluated by visual analogue scale (VAS) at baseline and the third and sixth months of the treatment.Results Of the 116 women, 94 including 51 women from group A ((61.23 +/- 8.20) years) and 43 women from group B ((63.73 +/- 5.45) years), completed the study. There were no significant differences in baseline characteristics including age, BMI, menopausal years, lumbar BMD, femoral neck BMD, and VAS between the two groups. The lumbar BMD of the 51 women in group A increased by 1.3% (p = 0.034) after vibration treatment for 3 months and by 4.3% at the sixth month (P=0.000). The lumbar BMD in group B was decreased at the third month, but there was not statistical significance (P>0.05). At the sixth month, it was decreased by 1.9% (P 0.05). At the sixth month, the BMD was increased by 3.2% (P