Crossed Aphasia in a Dextral Patient With Logopenic/Phonological Variant of Primary Progressive Aphasia
Crossed Aphasia in a Dextral Patient With Logopenic/Phonological Variant of Primary Progressive Aphasia
复制标题
DOI：
10.1097/wad.0b013e31823346c6
复制
发表时间：
2012-07-01
影响因子：
2.1
通讯作者：
Emre, Murat
中科院分区：
文献类型：
--
作者：
Demirtas-Tatlidede, Asli;Gurvit, Hakan;Emre, Murat
背景：交叉性失语症是一种罕见的现象，在所有右利手患者中的患病率为1%至2%。两个交叉性失语症患者的非流利型原发性进行性失语症（PPA）已被报告。本报告的目的是记录第一次发生交叉性逻辑缺失进行性失语症的右手patient.Case报告：一个57岁的单语家庭主妇提出了字查找困难。她是一个右撇子，没有左半球脑损伤的临床病史，她的家族史中也没有左撇子。她的语言由简单、语法正确的句子组成，语速起伏不定，还有间歇性的找词停顿。罕见的语音错误被注意到。句子重复任务表现出损害与语法复杂的句子。理解能力完好，书写和阅读也是如此。语言障碍被隔离了3年。头颅磁共振成像描绘了不对称的萎缩顶叶（R > L），而单光子发射计算机断层扫描成像显示在右顶叶皮层灌注不足，表明右半球优势language.Conclusions：本病例报告提供的证据表明，交叉PPA可以呈现出一个logopenic的变种，除了由其他人表现出的nonfluent类型。功能性神经影像学显示，在这种情况下，意外的右侧低灌注，只有微妙的结构性脑不对称，暗示语言优势的反向模式。
Background: Crossed aphasia is a rare phenomenon, with a prevalence of 1% to 2% among all right-handed patients. Two crossed aphasic patients with a nonfluent variant of primary progressive aphasia (PPA) have been reported previously. This report aims to document for the first time the occurrence of crossed logopenic progressive aphasia in a dextral patient.Case Report: A 57-year-old monolingual housewife presented with word-finding difficulties. She was strongly right handed, had no clinical history for brain damage to the left hemisphere, and no left handers in her family history. Her language comprised simple, grammatically correct sentences with a fluctuating speech rate and intermittent word-finding pauses. Rare phonological errors were noted. Sentence repetition tasks showed impairments with grammatically complex sentences. Comprehension was intact as were writing and reading. The language disability remained isolated for 3 years. Cranial magnetic resonance imaging depicted somewhat asymmetrical atrophy of the parietal lobes (R > L), whereas single-photon-emitted computed tomographic imaging demonstrated hypoperfusion in the right parietal cortex, indicating right hemisphere dominance for language.Conclusions: This case report provides evidence that crossed PPA can present with a logopenic variant in addition to the nonfluent type demonstrated by others. Functional neuroimaging showed unexpected right-sided hypoperfusion in this case with only subtle structural brain asymmetry, implicating a reverse pattern of language dominance.