Solid-Phase Modular Synthesis of Park Nucleotide and Lipids I and II Analogues
Solid-Phase Modular Synthesis of Park Nucleotide and Lipids I and II Analogues
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DOI：
10.1248/cpb.c17-00828
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发表时间：
2018-01-01
影响因子：
1.7
通讯作者：
Ichikawa, Satoshi
中科院分区：
文献类型：
--
作者：
Katsuyama, Akira;Sato, Kousuke;Ichikawa, Satoshi
本工作描述了一种适用于合成一系列类似物的Park核苷酸以及脂类I和II类似物的固相合成方法。这种技术允许高度官能化的大分子被模块化标记。在短时间(4d)内使用多个步骤，其中只有一个纯化步骤，通过固相合成来合成分子。
A solid-phase synthesis of Park nucleotide as well as lipids I and II analogues, which is applicable to the synthesis of a range of analogues, is described in this work. This technique allows highly functionalized macromolecules to be modularly labeled. Multiple steps are used in a short time (4d) with a single purification step to synthesize the molecules by solid-phase synthesis.