MERS CoV Infection in Two Renal Transplant Recipients: Case Report
MERS CoV Infection in Two Renal Transplant Recipients: Case Report
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DOI：
10.1111/ajt.13085
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发表时间：
2015-04-01
影响因子：
8.8
通讯作者：
Shalhoub, S.
中科院分区：
文献类型：
--
作者：
AlGhamdi, M.;Mushtaq, F.;Shalhoub, S.
中东呼吸综合征冠状病毒（MERS CoV）感染最近已成为严重的潜在致命肺炎的原因。临床表现从无症状感染到严重肺炎和急性肾功能衰竭。缺乏实体器官移植受者临床表现的数据。我们报告了两名肾移植受者的两例中东呼吸综合征冠状病毒感染病例，其临床表现和结果各不相同。第一位患者出现进行性呼吸道症状、急性肾衰竭并死亡。第二名患者出现呼吸道症状，尽管最近接受了胸腺球蛋白诱导，但仍保持稳定并具有良好的临床恢复。这是肾移植受者感染中东呼吸综合征冠状病毒的罕见报告。需要进一步的数据来更好地了解抗排斥免疫抑制治疗对实体器官移植受者中中东呼吸综合征冠状病毒感染的临床表现、严重程度和结果的影响。
Middle East Respiratory Syndrome Coronavirus (MERS CoV) infection has recently emerged as a cause of severe potentially fatal pneumonia. The clinical presentation ranges from asymptomatic infection to severe pneumonia and acute renal failure. Data on the clinical presentation in solid organ transplant recipients are lacking. We report two cases of MERS CoV infections in two renal transplant recipients with variable clinical presentations and outcomes. The first patient presented with progressive respiratory symptoms, acute renal failure and died. While the second patient presented with respiratory tract symptoms, remained stable and had an excellent clinical recovery despite recent reception of thymoglobulin induction. This is a rare report of MERS CoV infection in renal transplant recipients. Further data are needed to gain better understanding of the impact of anti-rejection immunosuppressive therapy on the clinical presentation, severity and outcome of MERS CoV infections in solid organ transplant recipients.