ROLE OF CHEMORECEPTOR TRIGGER ZONE IN HISTAMINE-INDUCED EMESIS
ROLE OF CHEMORECEPTOR TRIGGER ZONE IN HISTAMINE-INDUCED EMESIS
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DOI：
10.1111/j.1476-5381.1968.tb08479.x
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发表时间：
1968-01-01
影响因子：
7.3
通讯作者：
DIXIT, KS
中科院分区：
文献类型：
--
作者：
BHARGAVA, KP;DIXIT, KS
1. 在未麻醉的狗中，通过长期植入的插管将组胺注射到脑室后，研究了组胺的催吐作用，以阐明位于后区的化学感受器触发区（CT-区）在催吐中的作用。 2.注射到侧脑室时，需要定期注射大约10倍大剂量的组胺（3毫克）才能产生呕吐，并且发生呕吐的潜伏期比注射到第四脑室时的潜伏期更长。这与组胺对 CT 区的作用一致。 3.双侧CT区消融后，脑室内注射组胺不再产生呕吐，即使注射剂量比经常引起CT区完整的狗呕吐的剂量大三到四倍。因此，狗因脑室内注射组胺而产生的呕吐完全是由对 CT 区的作用造成的。 4.肌内注射氯丙嗪或肌内或侧脑室注射两种抗组胺药赛克利嗪和美吡拉敏，可防止侧脑室注射组胺引起的呕吐。抗组胺药的这种保护作用（并未延伸到口服硫酸铜产生的呕吐）表明 CT 区存在组胺能受体。
1. In unanaesthetized dogs, the emetic action of histamine was studied after its injection into the cerebral venricles through chronically implanted cannulae in order to elucidate the role of the chemoreceptor trigger zone (CT-zone), situated in the area postrema, for this emesis. 2. On injection into the lateral cerebral ventricle, about 10 times larger doses of histamine (3 mg) were required regularly to produce emesis, and it occurred after a longer latency than on injection into the fourth ventricle. This is in accord with an action of histamine on the CT-zone. 3. After bilateral ablation of the CT-zone, intraventricular injections of histamine no longer produced emesis even when injected in doses which were three to four times greater than those which regularly elicited vomiting in dogs with intact CT-zone. The emesis produced in dogs by intraventricular injections of histamine is thus fully accounted for by an action on the CT-zone. 4. Injections of chlorpromazine intramuscularly or of the two antihistamines cyclizine and mepyramine, either intramuscularly or into the lateral ventricle, prevented the emesis caused by histamine injected into the lateral ventricle. This protective action of the antihistamines—which did not extend to the emesis produced by oral copper sulphate—suggests the presence of histaminergic receptors in the CT-zone.