Carbohydrates for improving the cognitive performance of independent-living older adults with normal cognition or mild cognitive impairment.
Carbohydrates for improving the cognitive performance of independent-living older adults with normal cognition or mild cognitive impairment.
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DOI：
10.1002/14651858.cd007220.pub2
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发表时间：
2011-04
期刊：
影响因子：
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通讯作者：
C. P. Ooi;S. Loke;Z. Yassin;T. Hamid
中科院分区：
文献类型：
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作者：
C. P. Ooi;S. Loke;Z. Yassin;T. Hamid
轻度认知障碍（MCI）是介于正常认知和痴呆之间的一种中间状态，其中日常功能基本上完好无损。这种情况可能为研究预防痴呆症提供了机会。碳水化合物是一种重要的、容易获得的宏量营养素，它会影响认知能力。更好地了解正常认知和轻度认知障碍中碳水化合物驱动的认知变化可能会提出预防或减少认知下降的方法。评估碳水化合物在改善老年人认知功能方面的有效性。检索策略我们在2010年6月22日检索了ALOIS，科克伦痴呆和认知改善组专业注册库，检索词为：碳水化合物或碳水化合物或单糖或二糖或寡糖或多糖或碳水化合物。ALOIS包含来自所有主要医疗保健数据库（科克伦图书馆、MEDLINE、EMBASE、PsycINFO、CINAHL、LILACS）以及许多试验数据库和灰色文献来源的记录。选择标准：所有随机对照试验（RCT），检查任何形式的碳水化合物在正常认知和MCI中的疗效。数据收集和分析一位综述作者选择并检索了相关文章进行进一步评估。其余作者独立评估是否应纳入任何检索到的试验。通过讨论解决了分歧。主要结果：目前还没有任何形式的碳水化合物的随机对照试验，涉及认知正常或轻度认知障碍的独立生活的老年人。专家结论：没有合适的随机对照试验可以作为推荐使用任何形式的碳水化合物来增强认知正常或轻度认知障碍的老年人的认知能力的依据。需要对许多不同的碳水化合物进行更多的研究，以梳理出复杂的营养问题，并进一步评估记忆力的改善。
BACKGROUND Mild cognitive impairment (MCI) is an intermediate state between normal cognition and dementia in which daily function is largely intact. This condition may present an opportunity for research into the prevention of dementia. Carbohydrate is an essential and easily accessible macronutrient which influences cognitive performance. A better understanding of carbohydrate-driven cognitive changes in normal cognition and mild cognitive impairment may suggest ways to prevent or reduce cognitive decline. OBJECTIVES To assess the effectiveness of carbohydrates in improving cognitive function in older adults. SEARCH STRATEGY We searched ALOIS, the Cochrane Dementia and Cognitive Improvement Group Specialized Register on 22 June 2010 using the terms: carbohydrates OR carbohydrate OR monosaccharides OR disaccharides OR oligosaccharides OR polysaccharides OR CARBS. ALOIS contains records from all major healthcare databases (The Cochrane Library, MEDLINE, EMBASE, PsycINFO, CINAHL, LILACS) as well as from many trial databases and grey literature sources. SELECTION CRITERIA All randomised controlled trials (RCT) that have examined the efficacy of any form of carbohydrates in normal cognition and MCI. DATA COLLECTION AND ANALYSIS One review author selected and retrieved relevant articles for further assessment. The remaining authors independently assessed whether any of the retrieved trials should be included. Disagreements were resolved by discussion. MAIN RESULTS There is no suitable RCT of any form of carbohydrates involving independent-living older adults with normal cognition or mild cognitive impairment. AUTHORS' CONCLUSIONS There are no suitable RCTs on which to base any recommendations about the use of any form of carbohydrate for enhancing cognitive performance in older adults with normal cognition or mild cognitive impairment. More studies of many different carbohydrates are needed to tease out complex nutritional issues and further evaluate memory improvement.