Combined liquid chromatography-Tandem mass spectrometry as an analytical method for high throughput screening for X-linked adrenoleukodystrophy and other peroxisomal disorders: Preliminary findings
Combined liquid chromatography-Tandem mass spectrometry as an analytical method for high throughput screening for X-linked adrenoleukodystrophy and other peroxisomal disorders: Preliminary findings
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DOI：
10.1016/j.ymgme.2006.05.001
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发表时间：
2006-09-01
影响因子：
3.8
通讯作者：
Moser, Hugo
中科院分区：
文献类型：
--
作者：
Hubbard, Walter C.;Moser, Ann B.;Moser, Hugo
利用联合液相色谱串联质谱（LC-MS/MS）作为分析方法，我们已经证明了10至60倍过量的溶血磷脂酰胆碱含有二十六烷酸（26：0）在干血点的滤纸基质从25例男性患者与X-连锁肾上腺脑白质营养不良和9例患者与过氧化物酶体生物合成障碍相比，19个控制。正常受试者与受影响受试者之间没有重叠。(c)2006年爱思唯尔公司All rights reserved.
Utilizing combined liquid chromatography tandem mass spectrometry (LC-MS/MS) as the analytical method, we have demonstrated a ten to sixtyfold excess of lysophosphatidyl choline containing hexacosanoic acid (26:0) in dried blood spots on a filter paper matrix from 25 male patients with X-linked adrenoleukodystrophy and nine patients with peroxisome biogenesis disorders compared to 19 controls. There was no overlap between normal subjects versus affected subjects. (c) 2006 Elsevier Inc. All rights reserved.