Plasmapheresis affects T helper type-1/T helper type-2 balance of circulating peripheral lymphocytes
Plasmapheresis affects T helper type-1/T helper type-2 balance of circulating peripheral lymphocytes
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DOI：
10.1046/j.1526-0968.2001.00386.x
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发表时间：
2001-12-01
期刊：
影响因子：
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通讯作者：
Shibuya, N
中科院分区：
文献类型：
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作者：
Goto, H;Matsuo, H;Shibuya, N
血浆置换术不仅可以清除体液因子，而且还可以调节细胞免疫。我们研究了血浆置换术是否影响3例神经免疫性疾病患者的辅助性T细胞1/辅助性T细胞2（Th 1/Th 2）的平衡。检测抗-CD 3和抗-CD 28刺激的外周血单个核细胞培养上清中干扰素-γ（IFN-γ）、白细胞介素-2（IL-2）和IL-4的产生。在2/3例患者中，血浆置换（免疫吸附或血浆置换）降低了Th 1/Th 2细胞因子比率。结果提示，血浆置换可引起外周血Th 1/Th 2平衡的改变。
Plasmapheresis not only removes humoral factors, but may also modulate cellular immunity. We investigated whether plasmapheresis influenced T helper type-1/T helper type-2 (Th1/Th2) cytokine-producing-cell balance in 3 patients with neuroimmunological disease. The production of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and IL-4 in the culture supernatant of peripheral blood mononuclear cells stimulated by anti-CD3 and anti-CD28 was assayed. In 2 of 3 patients, plasmapheresis (immunoadsorption or plasma exchange) reduced Th1/Th2 cytokine ratio. The results may suggest that plasmapheresis induces a shift of Th1/Th2 balance in peripheral blood.