Surface modulation of silicon nitride ceramics for orthopaedic applications
Surface modulation of silicon nitride ceramics for orthopaedic applications
复制标题
DOI：
10.1016/j.actbio.2015.08.014
复制
发表时间：
2015-10-15
影响因子：
9.7
通讯作者：
Pezzotti, Giuseppe
中科院分区：
文献类型：
--
作者：
Bock, Ryan M.;McEntire, Bryan J.;Pezzotti, Giuseppe
氮化硅(Si3N4)具有高强度和断裂韧性、固有的相稳定性、抗划伤性、低磨损性、生物兼容性、亲水性、良好的放射成像和抗细菌粘附性等材料性能的独特组合，所有这些都使其成为骨科植入物的诱人选择。与氧化物陶瓷不同，Si3N4的表面化学和表面形貌可以进行工程设计，以满足体内的潜在需求。在形态上，它可以被制造成具有超光滑或高度纤维化的表面结构。它的化学成分可以从类二氧化硅表面到主要由硅胺组成的表面。在本研究中，对Si3N4生物陶瓷进行了热、化学和机械处理，以引起表面组成和特征的变化。这些处理包括研磨和抛光，在氢氟酸溶液中蚀刻，以及在氮气或空气中加热。使用各种显微镜技术对处理后的表面进行了表征，以评估其形态。用X射线光电子能谱和拉曼光谱分别测定了其表面化学组成和物相组成。流动电位测量评估了表面电荷，而座式水滴技术评估了润湿行为。这些处理产生了显著的表面性质差异，等电点在2到5.6之间，中等到极亲水的接触角从相似的65度到相似的8度。这项工作为将来的体外和体内研究提供了基础，这些研究将检验这些处理对重要的骨科性能的影响，如摩擦、磨损、蛋白质吸附、抑菌和骨整合。氮化硅(Si3N4)具有独特的整体机械和表面化学性能的组合，使其成为骨科植入物的理想生物材料。它已经被用于椎体间脊柱融合器，并正在开发用于全关节置换术。其表面纹理和化学成分都是高度可调的，可产生物理化学组合，在不影响整体机械性能的情况下，可能会增强骨整合和细菌耐药性。这项研究表明，Si3N4的S表面相组成、电荷和润湿行为可以很容易地发生重大变化，这是从机理上理解植入物表面与生物环境之间相互作用的第一步。(C)2015 Acta Materialia Inc.由爱思唯尔有限公司出版。版权所有。
Silicon nitride (Si3N4) has a distinctive combination of material properties such as high strength and fracture toughness, inherent phase stability, scratch resistance, low wear, biocompatibility, hydrophilic behavior, excellent radiographic imaging and resistance to bacterial adhesion, all of which make it an attractive choice for orthopaedic implants. Unlike oxide ceramics, the surface chemistry and topography of Si3N4 can be engineered to address potential in vivo needs. Morphologically, it can be manufactured to have an ultra-smooth or highly fibrous surface structure. Its chemistry can be varied from that of a silica-like surface to one which is predominately comprised of silicon-amines. In the present study, a Si3N4 bioceramic was subjected to thermal, chemical, and mechanical treatments in order to induce changes in surface composition and features. The treatments included grinding and polishing, etching in aqueous hydrofluoric acid, and heating in nitrogen or air. The treated surfaces were characterized using a variety of microscopy techniques to assess morphology. Surface chemistry and phase composition were determined using X-ray photoelectron and Raman spectroscopy, respectively. Streaming potential measurements evaluated surface charging, and sessile water drop techniques assessed wetting behavior. These treatments yielded significant differences in surface properties with isoelectric points ranging from 2 to 5.6, and moderate to extremely hydrophilic water contact angles from similar to 65 degrees to similar to 8 degrees. This work provides a basis for future in vitro and in vivo studies which will examine the effects of these treatments on important orthopaedic properties such as friction, wear, protein adsorption, bacteriostasis and osseointegration.Statement of SignificanceSilicon nitride (Si3N4) exhibits a unique combination of bulk mechanical and surface chemical properties that make it an ideal biomaterial for orthopaedic implants. It is already being used for interbody spinal fusion cages and is being developed for total joint arthroplasty. Its surface texture and chemistry are both highly tunable, yielding physicochemical combinations that may lead to enhanced osseointegration and bacterial resistance without compromising bulk mechanical properties. This study demonstrates the ease with which significant changes to Si3N4's surface phase composition, charging, and wetting behavior can be induced, and represents an initial step towards a mechanistic understanding of the interaction between implant surfaces and the biologic environment. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.